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Sipeimine-3-β-D-glucoside

$98$210

  • Brand : BIOFRON

  • Catalogue Number : BD-P0906

  • Specification : 98.5%(HPLC)

  • CAS number : 67968-40-5

  • PUBCHEM ID : 132538

Quantity
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Catalogue Number

BD-P0906

Analysis Method

HPLC,NMR,MS

Specification

98.5%(HPLC)

Storage

2-8°C

Molecular Weight

Appearance

Powder

Botanical Source

Structure Type

Alkaloids

Category

SMILES

CC1CCC2C(C3CCC4C(C3CN2C1)CC5C4CC(=O)C6C5(CCC(C6)OC7C(C(C(C(O7)CO)O)O)O)C)(C)O

Synonyms

(1R,2S,6S,9S,10S,11R,14S,15S,18S,20S,23R,24S)-10-hydroxy-6,10,23-trimethyl-20-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-azahexacyclo[12.11.0.02,11.04,9.015,24.018,23]pentacosan-17-one

IUPAC Name

(1R,2S,6S,9S,10S,11R,14S,15S,18S,20S,23R,24S)-10-hydroxy-6,10,23-trimethyl-20-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-azahexacyclo[12.11.0.02,11.04,9.015,24.018,23]pentacosan-17-one

Applications

Density

1.2±0.1 g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

Boiling Point

Melting Point

InChl

InChI=1S/C33H53NO8/c1-16-4-7-27-33(3,40)22-6-5-18-19(21(22)14-34(27)13-16)11-23-20(18)12-25(36)24-10-17(8-9-32(23,24)2)41-31-30(39)29(38)28(37)26(15-35)42-31/h16-24,26-31,35,37-40H,4-15H2,1-3H3/t16-,17-,18+,19+,20-,21-,22+,23-,24+,26+,27-,28+,29-,30+,31+,32+,33-/m0/s1

InChl Key

DHQFYEJMFMYGCV-DLJWJMOOSA-N

WGK Germany

RID/ADR

HS Code Reference

2933990000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:67968-40-5) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

26426971

Abstract

Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and shape change as people grow older and these changes differ substantially between men and women. To systematically screen for age- and/or sex-specific effects of genetic variants on BMI and WHRadjBMI, we performed meta-analyses of 114 studies (up to 320,485 individuals of European descent) with genome-wide chip and/or Metabochip data by the Genetic Investigation of Anthropometric Traits (GIANT) Consortium. Each study tested the association of up to ~2.8M SNPs with BMI and WHRadjBMI in four strata (men ≤50y, men >50y, women ≤50y, women >50y) and summary statistics were combined in stratum-specific meta-analyses. We then screened for variants that showed age-specific effects (G x AGE), sex-specific effects (G x SEX) or age-specific effects that differed between men and women (G x AGE x SEX). For BMI, we identified 15 loci (11 previously established for main effects, four novel) that showed significant (FDR<5%) age-specific effects, of which 11 had larger effects in younger (<50y) than in older adults (≥50y). No sex-dependent effects were identified for BMI. For WHRadjBMI, we identified 44 loci (27 previously established for main effects, 17 novel) with sex-specific effects, of which 28 showed larger effects in women than in men, five showed larger effects in men than in women, and 11 showed opposite effects between sexes. No age-dependent effects were identified for WHRadjBMI. This is the first genome-wide interaction meta-analysis to report convincing evidence of age-dependent genetic effects on BMI. In addition, we confirm the sex-specificity of genetic effects on WHRadjBMI. These results may provide further insights into the biology that underlies weight change with age or the sexually dimorphism of body shape.

Title

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

Author

Thomas W. Winkler,# 1 Anne E. Justice,# 2 Mariaelisa Graff,# 2 Llilda Barata,# 3 Mary F. Feitosa, 3 Su Chu, 4 Jacek Czajkowski, 3 Tõnu Esko, 5 , 6 , 7 , 8 Tove Fall, 9 , 10 Tuomas O. Kilpelainen, 11 , 12 Yingchang Lu, 13 , 14 Reedik Magi, 7 , 15 Evelin Mihailov, 7 Tune H. Pers, 6 , 8 , 16 Sina Rueger, 17 , 18 Alexander Teumer, 19 , 20 Georg B. Ehret, 21 , 22 Teresa Ferreira, 15 Nancy L. Heard-Costa, 23 , 24 Juha Karjalainen, 25 Vasiliki Lagou, 15 , 26 Anubha Mahajan, 15 Michael D. Neinast, 27 Inga Prokopenko, 15 , 26 , 28 , 29 Jeannette Simino, 30 Tanya M. Teslovich, 4 Rick Jansen, 31 Harm-Jan Westra, 32 , 33 , 34 Charles C. White, 35 Devin Absher, 36 Tarunveer S. Ahluwalia, 11 , 37 , 38 Shafqat Ahmad, 39 Eva Albrecht, 40 Alexessander Couto Alves, 41 Jennifer L. Bragg-Gresham, 4 Anton J. M. de Craen, 42 Joshua C. Bis, 43 , 44 Amelie Bonnefond, 45 , 46 , 47 Gabrielle Boucher, 48 Gemma Cadby, 49 Yu-Ching Cheng, 50 , 51 Charleston W. K. Chiang, 52 Graciela Delgado, 53 Ayse Demirkan, 54 Nicole Dueker, 55 Niina Eklund, 56 , 57 , 58 Gudny Eiriksdottir, 59 Joel Eriksson, 60 Bjarke Feenstra, 61 Krista Fischer, 7 Francesca Frau, 62 , 63 Tessel E. Galesloot, 64 Frank Geller, 61 Anuj Goel, 15 , 65 Mathias Gorski, 1 , 66 Tanja B. Grammer, 53 Stefan Gustafsson, 9 , 10 Saskia Haitjema, 67 Jouke-Jan Hottenga, 68 Jennifer E. Huffman, 24 , 69 Anne U. Jackson, 4 Kevin B. Jacobs, 70 , 71 asa Johansson, 9 , 72 Marika Kaakinen, 41 , 73 Marcus E. Kleber, 53 Jari Lahti, 74 , 75 Irene Mateo Leach, 76 Benjamin Lehne, 77 Youfang Liu, 78 Ken Sin Lo, 48 Mattias Lorentzon, 60 Jian'an Luan, 12 Pamela A. F. Madden, 79 Massimo Mangino, 80 Barbara McKnight, 43 , 81 , 82 Carolina Medina-Gomez, 83 , 84 , 85 Keri L. Monda, 2 , 86 May E. Montasser, 87 Gabriele Muller, 88 Martina Muller-Nurasyid, 40 , 89 , 90 , 91 Ilja M. Nolte, 92 Kalliope Panoutsopoulou, 93 Laura Pascoe, 94 Lavinia Paternoster, 95 Nigel W. Rayner, 15 , 26 , 93 Frida Renstrom, 39 Federica Rizzi, 62 , 63 Lynda M. Rose, 96 Kathy A. Ryan, 87 Perttu Salo, 56 , 57 Serena Sanna, 97 Hubert Scharnagl, 98 Jianxin Shi, 99 Albert Vernon Smith, 59 , 100 Lorraine Southam, 15 , 93 Alena Stancakova, 101 Valgerdur Steinthorsdottir, 102 Rona J. Strawbridge, 103 , 104 Yun Ju Sung, 30 Ioanna Tachmazidou, 93 Toshiko Tanaka, 105 Gudmar Thorleifsson, 102 Stella Trompet, 42 , 106 Natalia Pervjakova, 7 , 57 , 107 , 108 Jonathan P. Tyrer, 109 Liesbeth Vandenput, 60 Sander W van der Laan, 67 Nathalie van der Velde, 85 , 110 Jessica van Setten, 111 Jana V. van Vliet-Ostaptchouk, 112 Niek Verweij, 76 Efthymia Vlachopoulou, 113 Lindsay L. Waite, 36 Sophie R. Wang, 8 , 32 , 114 , 115 Zhaoming Wang, 70 , 71 Sarah H. Wild, 116 Christina Willenborg, 117 , 118 James F. Wilson, 119 Andrew Wong, 120 Jian Yang, 121 Loïc Yengo, 45 , 46 , 47 Laura M. Yerges-Armstrong, 87 Lei Yu, 122 Weihua Zhang, 77 , 123 Jing Hua Zhao, 12 Ehm A. Andersson, 11 Stephan J. L. Bakker, 124 Damiano Baldassarre, 125 , 126 Karina Banasik, 11 Matteo Barcella, 62 Cristina Barlassina, 62 Claire Bellis, 127 , 128 Paola Benaglio, 129 , 130 John Blangero, 127 Matthias Bluher, 131 , 132 Fabrice Bonnet, 133 Lori L. Bonnycastle, 134 Heather A. Boyd, 61 Marcel Bruinenberg, 135 Aron S Buchman, 122 Harry Campbell, 119 Yii-Der Ida Chen, 136 Peter S. Chines, 134 Simone Claudi-Boehm, 137 John Cole, 50 , 138 Francis S. Collins, 134 Eco J. C. de Geus, 68 , 139 Lisette C. P. G. M. de Groot, 140 Maria Dimitriou, 93 , 141 Jubao Duan, 142 , 143 Stefan Enroth, 9 , 72 Elodie Eury, 45 , 46 , 47 Aliki-Eleni Farmaki, 144 Nita G. Forouhi, 12 Nele Friedrich, 145 Pablo V. Gejman, 142 , 143 Bruna Gigante, 146 Nicola Glorioso, 147 Alan S. Go, 148 Omri Gottesman, 13 , 149 Jurgen Graßler, 150 Harald Grallert, 151 , 152 , 153 Niels Grarup, 11 Yu-Mei Gu, 154 Linda Broer, 85 Annelies C. Ham, 85 Torben Hansen, 11 , 155 Tamara B. Harris, 156 , 157 Catharina A. Hartman, 158 Maija Hassinen, 159 Nicholas Hastie, 69 Andrew T. Hattersley, 160 Andrew C. Heath, 79 Anjali K. Henders, 161 Dena Hernandez, 162 Hans Hillege, 76 Oddgeir Holmen, 163 Kees G Hovingh, 164 Jennie Hui, 165 , 166 , 167 Lise L. Husemoen, 168 Nina Hutri-Kahonen, 169 , 170 Pirro G. Hysi, 80 Thomas Illig, 151 , 171 , 172 Philip L. De Jager, 32 , 173 , 174 Shapour Jalilzadeh, 15 , 65 Torben Jørgensen, 168 , 175 , 176 J. Wouter Jukema, 106 , 177 Markus Juonala, 178 , 179 , 180 Stavroula Kanoni, 93 , 181 Maria Karaleftheri, 182 Kay Tee Khaw, 183 Leena Kinnunen, 184 Steven J. Kittner, 50 , 138 Wolfgang Koenig, 185 Ivana Kolcic, 186 Peter Kovacs, 131 Nikolaj T. Krarup, 11 Wolfgang Kratzer, 137 Janine Kruger, 187 Diana Kuh, 120 Meena Kumari, 188 Theodosios Kyriakou, 15 , 65 Claudia Langenberg, 12 , 188 Lars Lannfelt, 189 Chiara Lanzani, 190 , 191 Vaneet Lotay, 192 Lenore J. Launer, 157 Karin Leander, 146 Jaana Lindstrom, 193 Allan Linneberg, 168 , 175 , 194 Yan-Ping Liu, 154 Stephane Lobbens, 45 , 46 , 47 Robert Luben, 195 Valeriya Lyssenko, 37 , 196 Satu Mannisto, 56 Patrik K. Magnusson, 197 Wendy L. McArdle, 198 Cristina Menni, 80 Sigrun Merger, 137 Lili Milani, 7 Grant W. Montgomery, 161 Andrew P. Morris, 15 , 199 Narisu Narisu, 134 Mari Nelis, 7 Ken K. Ong, 12 , 120 , 200 Aarno Palotie, 58 , 93 , 201 Louis Perusse, 202 , 203 Irene Pichler, 204 Maria G. Pilia, 97 Anneli Pouta, 205 , 206 Myriam Rheinberger, 66 Rasmus Ribel-Madsen, 11 Marcus Richards, 120 Kenneth M. Rice, 82 Treva K. Rice, 30 , 207 Carlo Rivolta, 130 Veikko Salomaa, 56 Alan R. Sanders, 142 , 143 Mark A. Sarzynski, 208 Salome Scholtens, 92 Robert A. Scott, 12 William R. Scott, 77 , 123 Sylvain Sebert, 73 Sebanti Sengupta, 4 Bengt Sennblad, 103 , 104 , 209 Thomas Seufferlein, 137 Angela Silveira, 103 , 104 P. Eline Slagboom, 210 Jan H. Smit, 31 Thomas H. Sparsø, 11 Kathleen Stirrups, 93 , 181 Ronald P. Stolk, 92 Heather M. Stringham, 4 Morris A Swertz, 25 Amy J. Swift, 134 Ann-Christine Syvanen, 9 , 211 Sian-Tsung Tan, 123 , 212 Barbara Thorand, 152 , 153 Anke Tonjes, 132 Angelo Tremblay, 202 Emmanouil Tsafantakis, 213 Peter J. van der Most, 92 Uwe Volker, 20 , 214 Marie-Claude Vohl, 203 , 215 Judith M. Vonk, 92 Melanie Waldenberger, 91 , 151 , 152 Ryan W. Walker, 13 , 14 Roman Wennauer, 216 Elisabeth Widen, 58 Gonneke Willemsen, 68 Tom Wilsgaard, 217 , 218 Alan F. Wright, 69 M. Carola Zillikens, 83 , 85 Suzanne C. van Dijk, 85 Natasja M. van Schoor, 139 , 219 Folkert W. Asselbergs, 220 , 221 , 222 Paul I. W. de Bakker, 111 , 223 Jacques S. Beckmann, 17 John Beilby, 165 , 166 David A. Bennett, 122 Richard N. Bergman, 224 Sven Bergmann, 17 , 130 Carsten A. Boger, 66 Bernhard O. Boehm, 137 , 225 , 226 , 227 Eric Boerwinkle, 228 Dorret I. Boomsma, 68 Stefan R. Bornstein, 229 Erwin P. Bottinger, 13 , 149 Claude Bouchard, 208 John C. Chambers, 77 , 123 , 230 Stephen J. Chanock, 70 , 81 Daniel I. Chasman, 96 , 173 Francesco Cucca, 97 , 231 Daniele Cusi, 62 , 232 George Dedoussis, 144 Jeanette Erdmann, 117 , 118 Johan G. Eriksson, 56 , 74 , 233 Denis A. Evans, 234 Ulf de Faire, 146 Martin Farrall, 15 , 65 , 235 Luigi Ferrucci, 105 Ian Ford, 236 Lude Franke, 25 , 76 Paul W. Franks, 39 , 237 , 238 Philippe Froguel, 45 , 46 , 47 Ron T. Gansevoort, 124 Christian Gieger, 151 , 152 Henrik Gronberg, 197 Vilmundur Gudnason, 59 , 100 Ulf Gyllensten, 9 , 72 Per Hall, 197 Anders Hamsten, 103 , 104 , 239 Pim van der Harst, 25 , 76 , 221 Caroline Hayward, 69 Markku Heliovaara, 184 Christian Hengstenberg, 91 , 240 Andrew A Hicks, 204 Aroon Hingorani, 222 Albert Hofman, 83 , 84 Frank Hu, 238 , 241 Heikki V. Huikuri, 242 Kristian Hveem, 163 Alan L. James, 243 Joanne M. Jordan, 78 Antti Jula, 56 Mika Kahonen, 244 , 245 Eero Kajantie, 193 , 246 Sekar Kathiresan, 32 , 247 , 248 Lambertus A. L. M. Kiemeney, 64 , 249 Mika Kivimaki, 188 Paul B. Knekt, 250 Heikki A. Koistinen, 250 , 251 , 252 Jaspal S. Kooner, 123 , 212 , 230 Seppo Koskinen, 184 Johanna Kuusisto, 101 Winfried Maerz, 53 , 98 Nicholas G Martin, 161 Markku Laakso, 101 Timo A. Lakka, 159 , 253 Terho Lehtimaki, 254 , 255 Guillaume Lettre, 48 , 256 Douglas F. Levinson, 257 Lars Lind, 211 Marja-Liisa Lokki, 113 Pekka Mantyselka, 258 , 259 Mads Melbye, 61 , 175 , 260 Andres Metspalu, 7 Braxton D. Mitchell, 51 , 261 Frans L. Moll, 262 Jeffrey C. Murray, 263 Arthur W. Musk, 264 Markku S. Nieminen, 265 Inger Njølstad, 217 , 218 Claes Ohlsson, 60 Albertine J. Oldehinkel, 266 Ben A. Oostra, 54 Lyle J Palmer, 267 , 268 James S. Pankow, 269 Gerard Pasterkamp, 67 Nancy L. Pedersen, 197 Oluf Pedersen, 11 Brenda W. Penninx, 31 Markus Perola, 7 , 56 , 58 Annette Peters, 91 , 151 , 152 Ozren Polašek, 119 , 186 Peter P. Pramstaller, 204 , 270 Bruce M. Psaty, 43 , 44 , 271 , 272 Lu Qi, 238 , 241 Thomas Quertermous, 260 Olli T. Raitakari, 273 , 274 Tuomo Rankinen, 208 Rainer Rauramaa, 159 , 275 Paul M. Ridker, 96 , 173 John D. Rioux, 48 , 256 Fernando Rivadeneira, 83 , 84 , 85 Jerome I. Rotter, 136 Igor Rudan, 119 Hester M. den Ruijter, 67 Juha Saltevo, 276 Naveed Sattar, 277 Heribert Schunkert, 91 , 240 Peter E. H. Schwarz, 229 Alan R. Shuldiner, 87 , 278 Juha Sinisalo, 265 Harold Snieder, 92 Thorkild I. A. Sørensen, 11 , 279 , 280 Tim D. Spector, 80 Jan A. Staessen, 154 , 281 Bandinelli Stefania, 282 Unnur Thorsteinsdottir, 102 , 283 Michael Stumvoll, 131 , 132 Jean-Claude Tardif, 48 , 256 Elena Tremoli, 125 , 126 Jaakko Tuomilehto, 193 , 284 , 285 , 286 Andre G. Uitterlinden, 83 , 84 , 85 Matti Uusitupa, 287 , 288 Andre L. M. Verbeek, 64 Sita H. Vermeulen, 64 , 289 Jorma S. Viikari, 180 Veronique Vitart, 69 Henry Volzke, 19 , 214 Peter Vollenweider, 290 Gerard Waeber, 290 Mark Walker, 32 , 291 Henri Wallaschofski, 145 , 214 Nicholas J. Wareham, 12 Hugh Watkins, 15 , 65 Eleftheria Zeggini, 93 CHARGE Consortium, 292 , ¶ DIAGRAM Consortium, 293 , ¶ GLGC Consortium, 294 , ¶ Global-BPGen Consortium, 295 , ¶ ICBP Consortium, 296 , ¶ MAGIC Consortium, 297 , ¶ Aravinda Chakravarti, 22 Deborah J. Clegg, 27 L. Adrienne Cupples, 24 , 35 Penny Gordon-Larsen, 298 , 299 Cashell E. Jaquish, 300 D. C. Rao, 3 , 30 , 207 Goncalo R. Abecasis, 4 Themistocles L. Assimes, 260 Inês Barroso, 93 , 301 , 302 Sonja I. Berndt, 70 Michael Boehnke, 4 Panos Deloukas, 93 , 181 , 303 Caroline S. Fox, 24 , 173 Leif C. Groop, 196 , 304 David J. Hunter, 5 , 238 , 241 , 305 Erik Ingelsson, 9 , 10 , 15 , 306 Robert C. Kaplan, 307 Mark I. McCarthy, 15 , 26 , 308 Karen L. Mohlke, 309 Jeffrey R. O'Connell, 87 David Schlessinger, 157 David P. Strachan, 310 Kari Stefansson, 102 , 283 Cornelia M. van Duijn, 54 , 83 , 311 Joel N. Hirschhorn, 5 , 6 , 8 Cecilia M. Lindgren, 5 , 15 Iris M. Heid, 1 , 40 , ‡ * Kari E. North, 312 , ‡ * Ingrid B. Borecki, 3 , ‡ * Zoltan Kutalik, 17 , 18 , 130 , ‡ * and Ruth J. F. Loos 12 , 13 , 14 , 313 , 314 , ‡ *

Publish date

2015 Oct;

PMID

30429861

Abstract

A high-density, high-resolution genetic map was constructed for bitter gourd (Momordica charantia L.). A total of 2013 high quality SNP markers binned to 20 linkage groups (LG) spanning a cumulative distance of 2329.2 cM were developed. Each LG ranging from 185.2 cM (LG-12) to 46.2 cM (LG-17) and average LG span of 116.46 cM. The number of SNP markers mapped in each LG varied from 23 markers in LG-20 to 146 markers in LG-1 with an average of 100.65 SNPs per LG. The average distance between markers was 1.16 cM across 20 LGs and average distance between the markers ranged from 0.70 (LG-4) to 2.92 (LG-20). A total of 22 QTLs for four traits (gynoecy, sex ratio, node and days at first female flower appearance) were identified and mapped on 20 LGs. The gynoecious (gy-1) locus is flanked by markers TP_54865 and TP_54890 on LG 12 at a distance of 3.04 cM to TP_54890 and the major QTLs identified for the earliness traits will be extremely useful in marker development and MAS for rapid development of various gynoecious lines with different genetic background of best combiner for development of early and high yielding hybrids in bitter gourd.

KEYWORDS

bitter gourd, earliness, genotyping-by-sequencing, gynoecy, mapping, sex ratio

Title

Mapping and QTL Analysis of Gynoecy and Earliness in Bitter Gourd (Momordica charantia L.) Using Genotyping-by-Sequencing (GBS) Technology

Author

P. Gangadhara Rao,1 Tusar Kanti Behera,1,* Ambika B. Gaikwad,2 Anilabh Das Munshi,1 Gograj Singh Jat,1 and G. Boopalakrishnan1

Publish date

2018;

PMID

28654327

Abstract

Living organisms sense and respond to light, a crucial environmental factor, using photoreceptors, which rely on bound chromophores such as retinal, flavins or linear tetrapyrroles for light sensing. The discovery of photoreceptors that sense light using 5′-deoxyadenosylcobalamin, a form of vitamin B12 that is best known as an enzyme cofactor, has expanded the number of known photoreceptor families and unveiled a new biological role of this vitamin. The prototype of these B12-dependent photoreceptors, CarH, is widespread in bacteria and mediates light-dependent gene regulation in a photoprotective cellular response. CarH activity as a transcription factor relies on the modulation of its oligomeric state by 5′-deoxyadenosylcobalamin and light. This review surveys current knowledge about these B12-dependent photoreceptors, their distribution and mode of action, and the structural and photochemical basis of how they orchestrate signal transduction and control gene expression.

KEYWORDS

photoregulation, photochemistry, CarH, transcriptional repressor, chromophore, optogenetics

Title

A New Facet of Vitamin B12: Gene Regulation by Cobalamin-Based Photoreceptors

Author

S. Padmanabhan,1 Marco Jost,2,6 Catherine L. Drennan,2,3,4 and Montserrat Elias-Arnanz5

Publish date

2020 Apr 13.