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Sodium glycocholate

$64

  • Brand : BIOFRON

  • Catalogue Number : BN-O1274

  • Specification : 98%(HPLC)

  • CAS number : 863-57-0

  • Formula : C26H42NNaO6

  • Molecular Weight : 487.6

  • PUBCHEM ID : 23670522

  • Volume : 20mg

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Catalogue Number

BN-O1274

Analysis Method

Specification

98%(HPLC)

Storage

2-8°C

Molecular Weight

487.6

Appearance

Botanical Source

Structure Type

Category

SMILES

CC(CCC(=O)NCC(=O)[O-])C1CCC2C1(C(CC3C2C(CC4C3(CCC(C4)O)C)O)O)C.[Na+]

Synonyms

Glycine, N-choloyl-, monosodium salt/sodium {[(3α,5β,7α,8ξ,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino}acetate/GLYCOCHOLIC ACID SODIUM SALT/Glycine, N-((3α,5β,7α,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl)-, monosodium salt (9CI)/Sodium {[(3α,5β,7α,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino}acetate/Glycine, N-[(3α,5β,7α,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]-, sodium salt (1:1)/Sodium glycocholate hydrate/glycine, N-[(3α,5β,7α,8ξ,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]-, sodium salt (1:1)

IUPAC Name

sodium;2-[[(4R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]acetate

Density

Solubility

Flash Point

372.3ºC

Boiling Point

692ºC at 760 mmHg

Melting Point

210-215 °C (subl.)(lit.)

InChl

InChl Key

OABYVIYXWMZFFJ-ZUHYDKSRSA-M

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:863-57-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

7714745

Abstract

Cholestyramine resin in a bile acid sequestrant which binds with bile salts in the intestinal lumen to increase the fecal excretion of bile salts and, thus, lower blood serum cholesterol. In order to gain a better understanding of the low in vivo potency of cholestyramine, in vitro equilibrium binding studies, water sorption studies, and resin capacity measurements were performed using cholestyramine and the bile salt sodium glycocholate. Equilibrium binding and water sorption studies entailed equilibrating cholestyramine (1.0-20 mg/mL) with solutions which varied in glycocholate anion concentration (0.20-16.5 mM) and chloride anion concentration (15-150 mM). The resin’s practical specific capacity for glycocholate was lower than the practical specific capacity for chloride. This difference suggests that the rigid, bulky bile salt was pore excluded from 10% of the resin’s ionogentic sites. A fundamental parameter called the capacity-corrected molar selectivity coefficient, KGC-Cl-, was postulated to describe the underlying binding phenomena and was determined by measuring the free glycocholate and chloride anion concentrations; KGC-Cl- ranged from 9.8 (+/- 0.7) to 18.6 (+/- 0.2) and depended on the square of the free chloride concentration. The capacity-corrected molar selectivity coefficient was larger than the molar selectivity coefficient due to pore exclusion of glycocholate. A more simple method to calculate the capacity-corrected molar selectivity coefficient which required less data gave similar values to the more rigorous method (r2 = 0.955).

Title

In vitro characterization of sodium glycocholate binding to cholestyramine resin.

Author

Polli JE1, Amidon GL.

Publish date

1995 Jan


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