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Sodium Houttuyfonate

$78

  • Brand : BIOFRON

  • Catalogue Number : BF-S3004

  • Specification : 98%

  • CAS number : 1847-58-1

  • Formula : C14H27NaO5S

  • Molecular Weight : 330.4

  • Volume : 25mg

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Catalogue Number

BF-S3004

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

330.4

Appearance

Powder

Botanical Source

Houttuynia cordata

Structure Type

Others

Category

SMILES

CCCCCCCCCCCCOC(=O)CS(=O)(=O)[O-].[Na+]

Synonyms

IUPAC Name

Density

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

Boiling Point

Melting Point

InChl

InChI=1S/C14H28O5S.Na/c1-2-3-4-5-6-7-8-9-10-11-12-19-14(15)13-20(16,17)18;/h2-13H2,1H3,(H,16,17,18);/q;+1/p-1

InChl Key

UAJTZZNRJCKXJN-UHFFFAOYSA-M

WGK Germany

RID/ADR

HS Code Reference

2915900000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:1847-58-1) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

30331832

Title

Statistical Report on the Sickness and Mortality among the Troops Serving in the Madras Presidency. Prepared from Official Documents Printed by Order of the Madras Government

Author

T. Graham Balfour, M. D.

Publish date

1847 Jul 1;

PMID

30750280

Title

Letter from Dr. Wm. T. G. Morton of Boston

Author

Dr. Wm. T. G. Morton

Publish date

1847 Oct;

Title

On ScurvyPart I.—Account of an Epidemic Scurvy Which Prevailed in the General Prison at Perth in 1846

Author

Robert Christison, M.D., V.P. R.S.E.

Publish date

1847 Jun;


Description :

Sodium houttuyfonate inhibits virulence related motility of Pseudomonas aeruginosa PUMID/DOI:26281603 Zhongguo Zhong Yao Za Zhi. 2015 Apr;40(8):1585-8. The plate assay results showed that the inhibitory action of Sodium houttuyfonate against swimming and twitching in 24 h and swarming in 48 h is dose-dependent; and bacteria nearly lost all of the motile activities under the concentration of 1 x minimum inhibitory concentration (MIC) (512 mg x L(-1) same as azithromycin positive group (1 x MIC, 16 mg x L(-1)). Furthermore, we found that the expression of structural gene flgB and pilG is down-regulated by Sodium houttuyfonate, which implies that inhibitory mechanism of Sodium houttuyfonate against motility of P. aeruginosa may be due to the inhibition of flagella and pili bioformation of P. aeruginosa by SR Therefore, our presented results firstly demonstrate that Sodium houttuyfonate effectively inhibits the motility activities of P. aeruginosa, and suggest that Sodium houttuyfonate could be a promising antipseudomonas agents in clinic. Sodium houttuyfonate inhibits inflammation by blocking the MAPKs/NF-κB signaling pathways in bovine endometrial epithelial cells. PUMID/DOI:25935757 Res Vet Sci. 2015 Jun;100:245-51. Sodium houttuyfonate (SH) has traditionally been used for the therapy of inflammatory diseases. In this research, we tried to assess the anti-inflammatory effects of Sodium houttuyfonate on LPS-induced bovine endometrial epithelial cell (bEEC) inflammation. Sodium houttuyfonate cell toxicity was measured using the MTT and LDH assays, and inflammatory cytokine expression was assessed by ELISA, qRT-PCR and Western blotting. We demonstrated that Sodium houttuyfonate was not cytotoxic to bEECs, and that it significantly decreased the LPS-induced mRNA and protein expression of tumor necrosis factor (TNF) α, interleukin (IL)-1β, IL-6 and IL-8. Furthermore, in LPS-induced bEECs, SH inhibited IκBα degradation and NF-κB p65 phosphorylation, and suppressed the phosphorylation of the mitogen-activated protein kinases (MAPKs), p38, c-Jun N-terminal kinase (JNK), and extracellular signal-regulated kinase (ERK). In conclusion, we found that Sodium houttuyfonate could effectively block the NF-κB-mediated signaling pathway and reduce the inflammatory process, thereby exerting a protective effect on bEECs.