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Sodium phytate

$52

Brand : BIOFRON
Catalogue Number : BN-O0011
Specification : 98%(HPLC)
CAS number : 14306-25-3
Formula : C6H6Na12O24P6
Molecular Weight : 923.81
PUBCHEM ID : 66391
Volume : 20mg

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Catalogue Number

BN-O0011

Analysis Method

Specification

98%(HPLC)

Storage

-20℃

Molecular Weight

923.81

Appearance

White powder

Botanical Source

This product is isolated and purified from the herbs of Oryza sativa

Structure Type

Category

SMILES

C1(C(C(C(C(C1OP(=O)([O-])[O-])OP(=O)([O-])[O-])OP(=O)([O-])[O-])OP(=O)([O-])[O-])OP(=O)([O-])[O-])OP(=O)([O-])[O-].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]

Synonyms

1,2,3,4,5,6-Cyclohexanehexol, hexakis(dihydrogen phosphate), sodium salt, (1α,2α,3α,4α,5α,6β)- (1:12)/Inositol hexaphosphoric acid/Dodecasodium (1R,2R,3r,4S,5S,6s)-1,2,3,4,5,6-cyclohexanehexayl hexakis(phosphate)/Sodium phytate/myo-Inositol hexakis(dihydrogen phosphate)/Inositol hexakisphosphate

IUPAC Name

Density

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

673.9ºC

Boiling Point

1190.7ºC at 760mmHg

Melting Point

InChl

InChl Key

KETSPIPODMGOEJ-UHFFFAOYSA-B

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:14306-25-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

32101746

Abstract

The transcriptional corepressor complex CoREST is one of seven histone deacetylase complexes that regulate the genome through controlling chromatin acetylation. The CoREST complex is unique in containing both histone demethylase and deacetylase enzymes, LSD1 and HDAC1, held together by the RCOR1 scaffold protein. To date, it has been assumed that the enzymes function independently within the complex. Now, we report the assembly of the ternary complex. Using both structural and functional studies, we show that the activity of the two enzymes is closely coupled and that the complex can exist in at least two distinct states with different kinetics. Electron microscopy of the complex reveals a bi-lobed structure with LSD1 and HDAC1 enzymes at opposite ends of the complex. The structure of CoREST in complex with a nucleosome reveals a mode of chromatin engagement that contrasts with previous models.

KEYWORDS

CoREST complex, RCOR1, HDAC1, LSD1, KDM1A, nucleosome, histone deacetylase, lysine demethylase

Title

Mechanism of Crosstalk between the LSD1 Demethylase and HDAC1 Deacetylase in the CoREST Complex

Author

Yun Song,1,6 Lisbeth Dagil,2,7 Louise Fairall,1 Naomi Robertson,3,8 Mingxuan Wu,4,10 T.J. Ragan,1 Christos G. Savva,1 Almutasem Saleh,1,11 Nobuhiro Morone,5 Micha B.A. Kunze,2,7 Andrew G. Jamieson,3,9 Philip A. Cole,4 D. Flemming Hansen,2,∗ and John W.R. Schwabe1,12,∗∗

Publish date

2020 Feb 25

PMID

31430451

Abstract

Clathrin-mediated endocytosis (CME) is key to maintaining the transmembrane protein composition of cells’ limiting membranes. During mammalian CME, a reversible phosphorylation event occurs on Thr156 of the μ2 subunit of the main endocytic clathrin adaptor, AP2. We show that this phosphorylation event starts during clathrin-coated pit (CCP) initiation and increases throughout CCP lifetime. μ2Thr156 phosphorylation favors a new, cargo-bound conformation of AP2 and simultaneously creates a binding platform for the endocytic NECAP proteins but without significantly altering AP2’s cargo affinity in vitro. We describe the structural bases of both. NECAP arrival at CCPs parallels that of clathrin and increases with μ2Thr156 phosphorylation. In turn, NECAP recruits drivers of late stages of CCP formation, including SNX9, via a site distinct from where NECAP binds AP2. Disruption of the different modules of this phosphorylation-based temporal regulatory system results in CCP maturation being delayed and/or stalled, hence impairing global rates of CME.

KEYWORDS

clathrin-mediated endocytosis, regulation by phosphorylation, AP2 endocytic adaptor, NECAP, SNX9, AAK1, Numb-associated kinases (NAK), NMR, crystallography, TIRF

Title

Temporal Ordering in Endocytic Clathrin-Coated Vesicle Formation via AP2 Phosphorylation

Author

Antoni G. Wrobel,1,8,9 Zuzana Kadlecova,1,8,10,∗ Jan Kamenicky,2 Ji-Chun Yang,3 Torsten Herrmann,4 Bernard T. Kelly,1 Airlie J. McCoy,1 Philip R. Evans,3 Stephen Martin,5 Stefan Muller,6 Filip Sroubek,2 David Neuhaus,3 Stefan Honing,7,∗∗ and David J. Owen1

Publish date

2019 Aug 19