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Sodium tauroursodeoxycholate

$96

  • Brand : BIOFRON

  • Catalogue Number : BN-O1276

  • Specification : 98%(HPLC)

  • CAS number : 35807-85-3

  • Formula : C26H44NNaO6S

  • Molecular Weight : 521.69

  • PUBCHEM ID : 46782978

  • Volume : 20mg

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Catalogue Number

BN-O1276

Analysis Method

Specification

98%(HPLC)

Storage

-20℃

Molecular Weight

521.69

Appearance

Powder

Botanical Source

Structure Type

Category

SMILES

CC(CCC(=O)NCCS(=O)(=O)[O-])C1CCC2C1(CCC3C2C(CC4C3(CCC(C4)O)C)O)C.[Na+]

Synonyms

Ursodeoxycholyltaurine sodium/Sodium tauroursodesoxycholate/tauroursodeoxycholic acid/Tauroursodeoxycholate sodium salt/Ethanesulfonic acid, 2-[[(3α,5β,7β)-3,7-dihydroxy-24-oxocholan-24-yl]amino]-, sodium salt (1:1)/Ursodeoxycholyltaurine-Na salt/Tauroursodeoxycholic acid sodium/sodium tauroursodeoxychoate/sodium tauroursodeoxycholate/Sodium 2-{[(3α,5β,7β)-3,7-dihydroxy-24-oxocholan-24-yl]amino}ethanesulfonate/tauroursodeoxycholic acid sodium salt/Tauroursodeoxycholate (Sodium)

IUPAC Name

Density

Solubility

>26.1mg/mL in DMSO

Flash Point

Boiling Point

Melting Point

InChl

InChl Key

IYPNVUSIMGAJFC-JUWYWQLMSA-M

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:35807-85-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

23416354

Abstract

Paraquat is a commonly used herbicide; however, it is highly toxic to humans and animals. Exposure to paraquat causes severe lung damage, leading to pulmonary fibrosis. However, it has not been well clarified as how paraquat causes cellular damage, and there is no established standard therapy for paraquat poisoning. Meanwhile, endoplasmic reticulum stress (ERS) is reported to be one of the causative factors in many diseases, although mammalian cells have a defense mechanism against ERS-induced apoptosis (unfolded protein response). Here, we demonstrated that paraquat changed the expression levels of unfolded protein response-related molecules, resulting in ERS-related cell death in human lung epithelial A549 cells. Moreover, treatment with sodium tauroursodeoxycholate (TUDCA), a chemical chaperone, crucially rescued cells from death caused by exposure to paraquat. These results indicate that paraquat toxicity may be associated with ERS-related molecules/events. Through chemical chaperone activity, treatment with TUDCA reduced paraquat-induced ERS and mildly suppressed cell death. Our findings also suggest that TUDCA treatment represses the onset of pulmonary fibrosis caused by paraquat, and therefore chemical chaperones may have novel therapeutic potential for the treatment of paraquat poisoning.

Copyright © 2013 Elsevier Inc. All rights reserved.

Title

Sodium tauroursodeoxycholate prevents paraquat-induced cell death by suppressing endoplasmic reticulum stress responses in human lung epithelial A549 cells.

Author

Omura T1, Asari M, Yamamoto J, Oka K, Hoshina C, Maseda C, Awaya T, Tasaki Y, Shiono H, Yonezawa A, Masuda S, Matsubara K, Shimizu K.

Publish date

2013 Mar 22

PMID

9314037

Abstract

We investigated the effect of sodium tauroursodeoxycholate (UR-906) on cholestasis in common bile duct-ligated rats in comparison with the effect of dehydrocholic acid. UR-906 (30-180 mumol/kg) and dehydrocholic acid (180 mumol/kg) were intravenously given once daily for consecutive 20 days in rats and the common bile duct was ligated for the last 10 days. On the next day after the last test drug administration, serum biochemical and plasma hemostatic variables were determined. UR-906 significantly ameliorated the elevation of serum cholesterol, phospholipid, bilirubin and bile acid concentrations in bile duct-ligated rats. UR-906 significantly suppressed the prolongation of plasma prothrombin time and activated partial thromboplastin time. Furthermore, UR-906 significantly suppressed the decreases in plasma coagulation factor II and X activities. However, dehydrocholic acid did not cause significant changes in any of the variables examined in this model. These results suggest that UR-906 has a beneficial effect against cholestasis induced by bile duct ligation in rats and that this drug may be useful in the treatment of clinical cholestatic disorders.

Title

Effect of sodium tauroursodeoxycholate (UR-906) on liver dysfunction in bile duct-ligated rats.

Author

Ishizaki K1, Kinbara S, Miyazawa N, Takeuchi Y, Hirabayashi N, Kasai H, Araki T.

Publish date

1997 Aug 27


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