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Sophoridine

$43

  • Brand : BIOFRON

  • Catalogue Number : BF-S2003

  • Specification : 98%

  • CAS number : 6882-68-4

  • Formula : C15H24N2O

  • Molecular Weight : 248.36

  • PUBCHEM ID : 165549

  • Volume : 20mg

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Catalogue Number

BF-S2003

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

248.36

Appearance

Off-White needle crystal

Botanical Source

Sophora flavescens

Structure Type

Alkaloids

Category

Standards;Natural Pytochemical;API

SMILES

C1CC2C3CCCN4C3C(CCC4)CN2C(=O)C1

Synonyms

1H,5H,10H-Dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one, dodecahydro-, (7aR,13aR,13bR,13cS)-/Allomatrine/(5β)-Matridin-15-one/Bio-0637/5-Epidihydrosophocarpine/Dihydro-5-episophocarpine/(7aR,13aR,13bR,13cS)-Dodecahydro-1H,5H,10H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one/sophoridine/matridin-15-one

IUPAC Name

(1R,2R,9R,17S)-7,13-diazatetracyclo[7.7.1.02,7.013,17]heptadecan-6-one

Density

1.2±0.1 g/cm3

Solubility

Methanol; Ethyl Acetate; Acetontrile; Water; DMSO

Flash Point

172.7±17.2 °C

Boiling Point

396.7±31.0 °C at 760 mmHg

Melting Point

InChl

InChI=1S/C15H24N2O/c18-14-7-1-6-13-12-5-3-9-16-8-2-4-11(15(12)16)10-17(13)14/h11-13,15H,1-10H2/t11-,12-,13-,15+/m1/s1

InChl Key

ZSBXGIUJOOQZMP-BHPKHCPMSA-N

WGK Germany

RID/ADR

HS Code Reference

2933990000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:6882-68-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

31872730

Abstract

Through investigation,it was found that the main disease of leaves was grey mold on Dendrobium officinale in Hubei province,which has a great impact on the yield and quality of D. officinale. The identification of morphological and molecular biological was used to prove that the pathogen was Botrytis cinerea. Through test the effect of 5 plant source fungicides and 4 antibiotic fungicides on mycelial growth of strain HS1,which proved 0. 3% eugenol had the best inhibitory effect,EC50 was 0. 29 mg·L-1,the second was1% osthol and EC50 was 1. 12 mg·L-1,the EC50 of 0. 5% matrine was 9. 16 mg·L-1,the EC50 of the other six fungicides was higher than 10 mg·L-1. The field control effect test proved that 0. 3% eugenol had the best control effect,reaching 89. 44%,secondly for 1%osthole,which was 77. 17%,0. 5% matrine was in the third place with 62. 37% of effective rate. However,the control effect of the other fungicides was less than 60%. The three plant-derived fungicides were safe for the produce of D. officinale and showed no phytotoxicity. The effect of these fungicides on the growth of D. candidum was tested,and proved that all the fungicides were safe and harmless to D. candidum. This study provides a research basis for the safe and effective prevention and control gray mold of D. officinale.

KEYWORDS

Botrytis cinerea; Dendrobium officinale; control; identification

Title

[Isolation and identification of pathogen of Dendrobium officinale gray mold and its prevention and control].

Author

You JM1, Guo J1, Li Z2, Yang Q3, Duan YY1, Guo XL1, Huang DY4, Zou ZL1, Guo HJ1.

Publish date

2019 Sep

PMID

31801708

Abstract

OBJECTIVE:
To explore the effects of matrine on the proliferation, tumor cell stemness, β-catenin transcriptional activity and AKT/GSK3β/β-catenin signaling pathway in human hepatocellular carcinoma (HCC) HepG2 and Huh7 cells.

METHODS:
The proliferation and colony formation ability of HepG2 and Huh7 cells treated with 200, 400, and 800 μg/mL matrine were evaluated with MTT assay and colony formation assay, respectively. Real-time quantitative PCR was performed to detect the mRNA expressions of CD90, epithelial cell adhesion molecule (EpCAM) and CD133, and dual-luciferase assay was used to detect the transcriptional activity of β-catenin in the treated cells. The effects of matrine on the expressions of protein kinase B (AKT), P-AKT, GSK-3β, P-GSK-3β, P-β-catenin and β-catenin proteins in the Wnt/β-catenin signaling pathway were assessed using Western blotting.

RESULTS:
Matrine inhibited the proliferation of the two HCC cell lines in a time- and concentration-dependent manner. The half-inhibitory concentrations of matrine were 2369, 1565 and 909.1 μg/mL at 24, 48 and 72 h in HepG2 cells, respectively, and were 1355, 781.8, and 612.8 μg/mL in Huh7 cells, respectively. Matrine concentrationdependently suppressed colony formation of the HCC cells, producing significant inhibitory effects at 400 μg/mL P < 0.01) and 800 μg/mL P < 0.001) in HepG2 cells and at 200 μg/mL P < 0.05), 400 μg/mL P < 0.01), and 800 μg/mL P < 0.001) in Huh7 cells. Matrine at 400 and 800 μg/mL significantly inhibited the mRNA expression of CD90, EpCAM and CD133 and the transcriptional level of β-catenin in both HepG2 and Huh7 cells P < 0.05 or 0.01). Matrine at 400 and 800 μg/mL also significantly decreased the protein levels of β-catenin, P-AKT and P-GSK-3β and increased the phosphorylation level of β-catenin in both of the cell lines.

CONCLUSIONS:
Matrine inhibits the proliferation, colony formation, and the expressions of tumor stem cell markers CD90, EpCAM and CD133 in both HepG2 and Huh7 cells probably by inhibiting Wnt/β-catenin signaling pathway and the transcriptional activity ofβ-catenin.

KEYWORDS

hepatocellular carcinoma; matrine; tumor cell stemness; β-catenin

Title

[Matrine suppresses stemness of hepatocellular carcinoma cells by regulating β-catenin signaling pathway].

Author

Dai M1, Cai Z2, Chen N3, Li J1, Wen J1, Tan L1, Guo D1.

Publish date

2019 Oct 30

PMID

31609606

Abstract

In continuation of our program to develop natural-product-based pesticidal candidates, matrinic/oxymatrinic amides were obtained through structural optimization of matrine. N’-(4-Fluoro)phenyl-N-(4-bromo)phenylsulfonyloxymatrinic amide (IIm) showed potent insecticidal activity against Mythimna separata. N-(Un)substituted phenylsulfonylmatrinic acids (3a-c) exhibited promising acaricidal activity against Tetranychus cinnabarinus. By qRT-PCR analysis of nAChR subunits and AChE genes and determination of AChE activity of (un)treated T. cinnabarinus, it suggested that the open lactam ring of matrine and carboxyl group and (4-methyl)phenylsulfonyl of N-(4-methyl)phenylsulfonylmatrinic acid (3b) were necessary for action with α2, α4, α5, and β3 nAChR subunits; compound 3b was an inhibitor of AChE in T. cinnabarinus, and AChE was one possible target of action in T. cinnabarinus against 3b; and compound 3b may be an antagonist of nAChR and AChE in T. cinnabarinus.

KEYWORDS

amide derivatives; antagonist; matrine; pesticidal activity; structural modification

Title

Preparation of Matrinic/Oxymatrinic Amide Derivatives as Insecticidal/Acaricidal Agents and Study on the Mechanisms of Action against Tetranychus cinnabarinus.

Author

Xu H1,2, Xu M1, Sun Z1, Li S1.

Publish date

2019 Nov 6


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