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Sulfaclozine

$96

  • Brand : BIOFRON

  • Catalogue Number : BN-O1212

  • Specification : 99%(HPLC)

  • CAS number : 102-65-8

  • Formula : C10H9ClN4O2S

  • Molecular Weight : 284.72

  • PUBCHEM ID : 66890

  • Volume : 5mg

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Catalogue Number

BN-O1212

Analysis Method

Specification

99%(HPLC)

Storage

2-8°C

Molecular Weight

284.72

Appearance

Botanical Source

Structure Type

Category

SMILES

C1=CC(=CC=C1N)S(=O)(=O)NC2=CN=CC(=N2)Cl

Synonyms

6-Chlor-2-sulfanilamino-pyrazin/sulfachloropyrazine/Sulfachlorpyrazin/Sulfaclozinum/4-amino-N-(6-chloropyrazin-2-yl)benzenesulfonamide/Benzenesulfonamide, 4-amino-N-(6-chloro-2-pyrazinyl)-/N-(6-chloropyrazinyl)sulfanilamide/Sulfaclozina/4-Amino-N-(6-chloro-2-pyrazinyl)benzenesulfonamide/Sulfaclozine

IUPAC Name

4-amino-N-(6-chloropyrazin-2-yl)benzenesulfonamide

Density

1.6±0.1 g/cm3

Solubility

Flash Point

253.6±31.5 °C

Boiling Point

495.7±55.0 °C at 760 mmHg

Melting Point

InChl

InChl Key

QKLPUVXBJHRFQZ-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:102-65-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

29134523

Abstract

Bicarbonate, phosphate, chloride ions, and humic substances are among the constituents most widely present in natural waters. These non-target constituents can greatly affect the efficiency of advanced oxidation processes used for water decontamination due to their capacity to interfere with the adsorption of the target compounds on the surface of TiO2, absorb photons, scavenge hydroxyl radicals (·OH), and generate photochemical reactive intermediates. In this work, the effect of these constituents on the degradation of sulfaclozine (SCL) was monitored in three different AOPs systems: UV/TiO2, UV/K2S2O8, and UV/TiO2/K2S2O8. It was shown that bicarbonate (HCO3-) and phosphate (HPO42-) ions enhanced the degradation of SCL in UV/TiO2 and UV/TiO2/K2S2O8 systems whereas the addition of humic substances influenced these rates with a much smaller extent. On the other hand, the degradation rate of SCL in the UV/K2S2O8 system was not affected by the presence of HCO3- and HPO42- but was inhibited in the presence of humic substances. In addition, the different mechanisms that can take place in the presence of these constituents were discussed and the degradation rate enhancement in presence of HCO3- and HPO42- was attributed to the formation of new reactive species such as carbonate (CO3·-) and hydroxyl (·OH) radicals activated by TiO2 holes (h+). In the presence of chloride (Cl-) and nitrate (NO3-) ions, an enhancement of SCL adsorption on the surface of TiO2 was observed. Finally, a comparative study of the degradation of SCL in river water and ultrapure water was reported.

KEYWORDS

Advanced oxidation processes; Bicarbonate; Hydroxyl radicals; Phosphate; Sulfaclozine; Sulfate radicals.

Title

Effect of Water Constituents on the Degradation of Sulfaclozine in the Three Systems: UV/TiO 2, UV/K 2 S 2 O 8, and UV/TiO 2/K 2 S 2 O 8

Author

Liliane Ismail 1 2, Corinne Ferronato 3, Ludovic Fine 3, Farouk Jaber 4 5, Jean-Marc Chovelon 3

Publish date

Jan-18

PMID

3750301

Abstract

Symptoms of paralysis were observed in seven-week-old turkeys on a farm following administration of sulphachlorpyrazine for coccidiosis. Paralysis was particularly common in the females which were separated from the male birds. Of monensin 122 ppm were found to be present in the feed, whereas the amount stated on the label was 100 ppm. When a new batch was substituted for this feed, the symptoms abated. As the result of a possible interaction of monensin and sulphachlorpyrazine, mortality was 1.7 per cent in the male and 11.2 per cent in the female birds.

Title

[Monensin/sulfachlorpyrazine Poisoning in Turkeys]

Author

W W Braunius

Publish date

1986 Jul 15

PMID

19887098

Abstract

In this study, 30-day-old, 14 male broiler chickens were used. Two groups, each comprising 7 animals, were established. While each animal included in the first group was administered sulfaclozine at a dose of 60 mg/kg bw by intravenous route (IV), group 2 was administered sulfaclozine at the same dose but by intracrop route (IC). In group 1, serum sulfaclozine concentrations at 0.083, 0.50, 2, 6, 24 and 72h were determined to be 99.62+/-3.31, 83.50+/-4.22, 72.68+/-5.02, 58.43+/-5.39, 38.66+/-4.04 and 13.14+/-1.64 microg/ml, respectively, via HPLC. In group 2, serum drug concentrations at 0.083, 0.50, 2, 6, 24 and 72h were determined as 4.33+/-0.45, 7.95+/-0.72, 16.46+/-2.68, 22.88+/-3.00, 16.03+/-3.53 and 5.74+/-0.98 microg/ml, respectively. Statistical analyses revealed that, of all the parameters studied, only A(1)( *), A(2)( *), alpha, beta, t(1/2)(alpha), t(1/2)(beta), MRT, Vd(area), k(12), k(21), AUC(0–>72) and AUC(0–>infinity) differed significantly between the groups (p<0.05). Compared to intravenous administration, significant increase in t(1/2)(alpha), t(1/2)(beta), MRT and Vd(area), and significant decrease in A(1)( *), A(2)( *), alpha, beta, k(12), k(21), AUC(0-->72) and AUC(0–>infinity) were observed in the group, which was administered sulfaclozine by intracrop route.

Copyright 2009 Elsevier Ltd. All rights reserved.

Title

Pharmacokinetic of Sulfaclozine in Broiler Chickens

Author

Ismail Sentepe 1, Gokhan Eraslan

Publish date

Jan-10


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