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Sulfaguanidine

$64

  • Brand : BIOFRON

  • Catalogue Number : BN-O1243

  • Specification : 99%(HPLC)

  • CAS number : 57-67-0

  • Formula : C7H10N4O2S

  • Molecular Weight : 214.25

  • PUBCHEM ID : 5324

  • Volume : 5mg

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Catalogue Number

BN-O1243

Analysis Method

Specification

99%(HPLC)

Storage

2-8°C

Molecular Weight

214.25

Appearance

Botanical Source

Structure Type

Category

SMILES

C1=CC(=CC=C1N)S(=O)(=O)N=C(N)N

Synonyms

Suganyl/Ruocid/Ganidan/Sulgin/sulfanilylguanidine/A-307/sulphaguanidine/Diacta/Sulfaguanidin/rp2275/4-aminobenzene-sulfonyl-guanidine/Aterian

IUPAC Name

2-(4-aminophenyl)sulfonylguanidine

Density

1.6±0.1 g/cm3

Solubility

Flash Point

211.5±29.3 °C

Boiling Point

426.1±47.0 °C at 760 mmHg

Melting Point

190-193°C

InChl

InChl Key

BRBKOPJOKNSWSG-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:57-67-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

29437626

Abstract

The high acquisition rate of drug resistance by Mycobacterium tuberculosis necessitates the ongoing search for new drugs to be incorporated in the tuberculosis (TB) regimen. Compounds used for the treatment of other diseases have the potential to be repurposed for the treatment of TB. In this study, a high-throughput screening of compounds against thiol-deficient Mycobacterium smegmatis strains and subsequent validation with thiol-deficient M. tuberculosis strains revealed that ΔegtA and ΔmshA mutants had increased susceptibility to azaguanine (Aza) and sulfaguanidine (Su); ΔegtB and ΔegtE mutants had increased susceptibility to bacitracin (Ba); and ΔegtA, ΔmshA, and ΔegtB mutants had increased susceptibility to fusaric acid (Fu). Further analyses revealed that some of these compounds were able to modulate the levels of thiols and oxidative stress in M. tuberculosis This study reports the activities of Aza, Su, Fu, and Ba against M. tuberculosis and provides a rationale for further investigations.

KEYWORDS

antimicrobial agents; oxidative stress; susceptibility testing; thiols.

Title

Compounds With Potential Activity Against Mycobacterium Tuberculosis

Author

C Sao Emani 1 2, M J Williams 3, I J Wiid 3, B Baker # 1, C Carolis # 4

Publish date

2018 Mar 27

PMID

29145096

Abstract

Sulfaguanidine (SG), belongs to the class of sulfonamide drug used as an effective antibiotic. In the present work, using crystal engineering approach two novel cocrystals of SG were synthesized (SG-TBA and SG-PT) with thiobarbutaric acid (TBA) and 1,10-phenanthroline (PT), characterized by solid state techniques viz., powder X-ray diffraction (PXRD), fourier transform infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC) and the crystal structures were determined by single crystal X-ray diffraction studies. A comparative antibacterial activity and hemolytic potential was done on SG drug, coformers and their cocrystals. The tested cocrystals formulations showed almost two fold higher antibacterial activity against the tested strains of bacteria Gram-positive bacteria (S. mutans and E. faecalis) and Gram-negative bacteria (E. coli, K. pneumonia and E. clocae) over SG alone and their coformers. Cocrystal SG-TBA showed better antibacterial activity and reduced hemolysis, thereby, reduced cytotoxicity than SG-PT.

KEYWORDS

Antibacterial; Cocrystals; Hemolytic potential; Sulfaguanidine.

Title

Sulfaguanidine Cocrystals: Synthesis, Structural Characterization and Their Antibacterial and Hemolytic Analysis

Author

Syed Sibte Asghar Abidi 1, Yasser Azim 2, Shahper Nazeer Khan 3, Asad U Khan 3

Publish date

2018 Feb 5

PMID

4594511

Title

[Dysentery]

Author

F Mihaljević

Publish date

Feb-74


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