Cinnamomum cassia Presl
Simple Phenolic Compounds
Syringic Aldehyde/4-Hydroxy-3,5-dimethoxybenzaldehyde/4-Hydroxy-3,5-dimethoxybenzolcarbaldehyd/Syringaldehyde/3,5-Dimethoxy-4-Hydroxybenzaldehyde/Benzaldehyde, 4-hydroxy-3,5-dimethoxy-
Syringaldehyde is a polyphenolic compound belonging to the group of flavonoids and is found in different plant species like Manihot esculenta and Magnolia officinalis. Syringaldehyde moderately inhibits COX-2 activity with an IC50 of 3.5 μg/mL. Anti-hyperglycemic and anti-inflammatory activities.
322.1±37.0 °C at 760 mmHg
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provides coniferyl ferulate(CAS#:134-96-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
Syringaldehyde is one of the active principles from the stems of Hibiscus taiwanensis (Malvaceae) that has been mentioned to lower hyperglycemia. However, the potential mechanisms for this action of syringaldehyde remain obscure. In the present study, we used streptozotocin to induce diabetic rats (STZ-diabetic rats) as type 1-like diabetic rats and fed fructose-rich chow to rats as type 2-like diabetic rats. Then, we performed the postprandial glucose test and applied the hyperinsulinemic euglycemic clamp to investigate the actions of syringaldehyde. Also, the changes of gene expressions of enzyme relating to glucose homeostasis in muscle and liver were characterized. Syringaldehyde significantly decreased the postprandial plasma glucose in rats, while the plasma insulin was not modified by syringaldehyde. The glucose infusion rate (GIR) in fructose chow-fed rats using hyperinsulinemic euglycemic clamp was markedly improved by syringaldehyde. Additionally, repeated administration of syringaldehyde for 3 days in STZ-diabetic rats resulted in a marked reduction of phosphoenolpyruvate carboxykinase (PEPCK) expression in liver and an increased expression of glucose transporter subtype 4 (GLUT 4) in skeletal muscle. Our results suggest that syringaldehyde may increase glucose utilization to lower hyperglycemia in diabetic rats.
© Georg Thieme Verlag KG Stuttgart · New York.
Decrease of Hyperglycemia by Syringaldehyde in Diabetic Rats
S C Kuo 1 , H H Chung 2 , C H Huang 3 , J T Cheng 4
The influence of different reaction conditions on the yield of syringaldehyde was studied by using perovskite oxide as the catalyst. The optimal reaction conditions are as follows: 0.60 g of dealkali lignin, 0.60 g of 5 wt % theta ring-loaded LaFe0.2Cu0.8O3 catalyst, 30 mL of 1.0 mol/L NaOH solution, 160 °C reaction temperature, 0.80 MPa O2 pressure, and 2.5 h reaction time. Under these conditions, the highest syringaldehyde yield was 10.00%. The recycling performance of the catalyst was studied. It was found by XRD analysis that the catalyst maintained high catalytic activity after four times of use.
Copyright © 2020 American Chemical Society.
Preparation of Syringaldehyde From Lignin by Catalytic Oxidation of Perovskite-Type Oxides
Ying-Xia Li 1 , Jun-Peng Zhu 1 2 , Zhong-Jun Zhang 1 2 , Yong-Shui Qu 2
2020 Jan 29
There are few studies on the neuroprotective effects of syringaldehyde in a rat model of cerebral ischemia. The study aimed to elucidate the mechanisms underlying the neuroprotective effects of syringaldehyde on ischemic brain cells. Rat models of cerebral ischemia were intraperitoneally administered syringaldehyde. At 6 and 24 hours after syringaldehyde administration, cell damage in the brain of cerebral ischemia rats was obviously reduced, superoxide dismutase activity and nuclear respiratory factor 1 expression in the brain tissue were markedly increased, malondiadehyde level was obviously decreased, apoptosis-related cysteine peptidase caspase-3 and -9 immunoreactivity was obviously decreased, and neurological function was markedly improved. These findings suggest that syringaldehyde exerts neuroprotective effects on cerebral ischemia injury through anti-oxidation and anti-apoptosis.
apoptosis; brain ischemia; inflammatory; nerve regeneration; neural regeneration; neuroprotective effects; oxidative stress; syringaldehyde.
Syringaldehyde Exerts Neuroprotective Effect on Cerebral Ischemia Injury in Rats Through Anti-Oxidative and Anti-Apoptotic Properties
Aras Adem Bozkurt 1 , Guven Mustafa 1 , Akman Tarık 1 , Ozkan Adile 2 , Sen Halil Murat 2 , Kılıcoglu Mesut 3 , Kalkan Yıldıray 4 , Silan Coskun 5 , Cosar Murat 1
2014 Nov 1