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Talatisamine

$225

  • Brand : BIOFRON

  • Catalogue Number : BF-T2010

  • Specification : 98%

  • CAS number : 20501-56-8

  • Formula : 24H39NO5

  • Molecular Weight : 421.57

  • PUBCHEM ID : 71307576

  • Volume : 20mg

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Catalogue Number

BF-T2010

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

421.57

Appearance

White crystalline powder

Botanical Source

roots of Aconitum carmichaeli Debx.

Structure Type

Alkaloids

Category

Standards;Natural Pytochemical;API

SMILES

CCN1CC2(CCC(C34C2CC(C31)C5(CC(C6CC4C5C6O)OC)O)OC)COC

Synonyms

talatizamine/Talatisamine/(1α,14α,16β)-20-Ethyl-1,16-dimethoxy-4-(methoxymethyl)aconitane-8,14-diol/20-Ethyl-1-α,16-β-dimethoxy-4-(methoxymethyl)aconitane-8,14-α-diol/Aconitane-8,14-diol, 20-ethyl-1,16-dimethoxy-4-(methoxymethyl)-, (1α,4β,14α,16β)-/(16S)-20-ethyl-1α,16-dimethoxy-4-methoxymethyl-aconitane-8,14α-diol/(16S)-20-Aethyl-1α,16-dimethoxy-4-methoxymethyl-aconitan-8,14α-diol/Aconitane-8,14-diol, 20-ethyl-1,16-dimethoxy-4-(methoxymethyl)-, (1α,14α,16β)-/(1α,4β,14α,16β)-20-Ethyl-1,16-dimethoxy-4-(methoxymethyl)aconitane-8,14-diol

IUPAC Name

(1S,2R,3R,4S,5S,6S,8S,9S,13R,16S,17R)-11-ethyl-6,16-dimethoxy-13-(methoxymethyl)-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadecane-4,8-diol

Density

1.3±0.1 g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

276.7±30.1 °C

Boiling Point

533.9±50.0 °C at 760 mmHg

Melting Point

151-152℃

InChl

InChI=1S/C24H39NO5/c1-5-25-11-22(12-28-2)7-6-18(30-4)24-14-8-13-16(29-3)10-23(27,19(14)20(13)26)15(21(24)25)9-17(22)24/h13-21,26-27H,5-12H2,1-4H3/t13-,14-,15+,16+,17-,18+,19-,20+,21?,22+,23+,24-/m1/s1

InChl Key

BDCURAWBZJMFIK-FLDLCTCNSA-N

WGK Germany

RID/ADR

HS Code Reference

2938900000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:20501-56-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

31207562

Abstract

Talatisamine, as the efficacy ingredient of Aconitum, was known as a novel specific blocker for the delayed rectifier K+ channels in rat hippocampal neurons. In this study, a rapid, selective and reproducible UPLC-MS/MS separation method was established and fully validated for the quantitative determination of talatisamine levels in ICR (Institute of Cancer Research) mouse blood. A total of 24 healthy male ICR mice were divided into four groups that was administered talatisamine via intravenous at a dose of 1 mg/kg and oral administration of three doses (2, 4, 8 mg/kg). All blood samples were protein precipitate by using acetonitrile with an internal standard (IS) deltaline. The effective chromatographic separation was carried out through an UPLC BEH C18 analytical column (2.1 mm × 50 mm, 1.7 μm) with an initial mobile phase that consisted of acetonitrile and 10 mmol/L ammonium acetate aqueous solution (containing 0.1% formic acid) with a gradient elution pumped at a flow rate of 0.4 mL/min. Also, an electrospray ionization (ESI) was applied to quantify the talatisamine in the positive ions mode. The method validation demonstrated good linearity over the range of 1-1000 ng/mL (r2 ≥ 0.9993) for talatisamine in mouse blood with a lower limit of quantification (LLOQ) at 1 ng/mL. The accuracy values of the method were within 89.4% to 113.3%, and the matrix effects were between 103.2% and 106.3%. The mean extraction recoveries for talatisamine obtained from four concentrations of QC blood samples were exceeded 71.7%, and the relative standard deviation (RSD) both of intra- and inter-day precision values for replicate quality control samples did not exceed 15% respectively for all analytes during the assay validation. This method was successfully applied to the evaluation of the pharmacokinetic of talatisamine, regardless of intragastric or intravenous administration in mice. Based on the pharmacokinetics data, the bioavailability of talatisamine in mice was >65.0% after oral administration, exhibiting an excellent oral absorption.

Copyright © 2019 Elsevier B.V. All rights reserved.

KEYWORDS

Bioavailability; Mice; Pharmacokinetics; Talatisamine; UPLC-MS/MS

Title

Quantitative determination of talatisamine and its pharmacokinetics and bioavailability in mouse plasma by UPLC-MS/MS.

Author

Chen M1, Chen Y1, Wang X2, Zhou Y3.

Publish date

2019 Aug 15

PMID

29212360

Abstract

A new denudatine-type C20-diterpenoid alkaloid, designated as sinchianine (1), together with eight known diterpenoid alkaloids, 12-acetyl-12-epi-napelline (2), 12-epi-napelline (3), neoline (4), talatisamine (5), 14-O-acetylsenbusine A (6) and benzoylaconine (7), songorine (8) and aconitine (9), were isolated from the whole herb of Aconitum sinchiangense W. T. Wang. Their structures were elucidated on the basis of extensive spectroscopic analyses (NMR and HR-ESI-MS) and comparison with data reported in the literature.

KEYWORDS

Aconitum sinchiangense W. T. Wang; denudatine-type; diterpenoid alkaloids; sinchianine

Title

A new denudatine type C20-diterpenoid alkaloid from Aconitum sinchiangense W. T. Wang

Author

Samanbay A1,2, Zhao B2,3, Aisa HA2,3.

Publish date

2018 Oct;

PMID

26767293

Abstract

OBJECTIVE:
To investigate the chemical constituents of the processed products of Aconitum Vilmorinian Radix.

METHODS:
The constituents were isolated by repeated column chromatography over silica gel, alumina and RP-C18 as well as recrystallization. The structures were elucidated on the basis of spectral analysis and physicochemical properties.

RESULTS:
Ten compounds were obtained from the methanol extract, and they were identified as yunaconitine (1), 8-deacetyl-yunaconitine (2), geniculatine C (3), vilmorrianine B (4), vilmorrianine C(5), vilmorrianine D (6), talatisamine (7), β-sitosterol (8), β-daucosterol (9) and β-sitosterol acetate (10).

CONCLUSION:
All compounds are obtained from the processed products of Aconitum Vilmoriniani Radix for the first time.

Title

[Chemical Constituents from Processed Products of Aconitum Vilmoriniani Radix].

Author

Guo ZJ, Yang ZY, Tan WH, Zhou ZH, Ma XX.

Publish date

2015 May


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