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Tanshinone IIA-sulfonic sodium

$43

  • Brand : BIOFRON

  • Catalogue Number : BF-T2002

  • Specification : 98%

  • CAS number : 69659-80-9

  • Formula : C19H17O6S.Na

  • Molecular Weight : 396.39

  • PUBCHEM ID : 23669322

  • Volume : 20mg

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Catalogue Number

BF-T2002

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

-20℃

Molecular Weight

396.39

Appearance

Dark Red crystals

Botanical Source

roots of Salvia miltiorrhiza

Structure Type

Terpenoids

Category

Standards;Natural Pytochemical;API

SMILES

CC(=O)C1=C(C=C(C=C1)OC)O

Synonyms

sodium,1,6,6-trimethyl-10,11-dioxo-8,9-dihydro-7H-naphtho[1,2-g][1]benzofuran-2-sulfonate/Sodium 1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-2-sulfonate/Phenanthro[1,2-b]furan-2-sulfonic acid, 6,7,8,9,10,11-hexahydro-1,6,6-trimethyl-10,11-dioxo-, sodium salt (1:1)/Tanshinone IIA sulfonate (sodium)/Sulfotanshinone sodium II-A

IUPAC Name

sodium;1,6,6-trimethyl-10,11-dioxo-8,9-dihydro-7H-naphtho[1,2-g][1]benzofuran-2-sulfonate

Density

Solubility

Flash Point

Boiling Point

Melting Point

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

2932990000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:69659-80-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

31545252

Abstract

Sodium tanshinone IIA sulfonate (STS) is a water-soluble derivate of tanshinone IIA (Tan IIA) which is an active lipophilic constitute of Chinese Materia Medica Salvia miltiorrhiza Bge. (Danshen). STS presents multiple pharmacological activities, including anti-oxidant, anti-inflammation and anti-apoptosis, and has been approved for treatment of cardiovascular diseases by China State Food and Drug Administration (CFDA). In this review, we comprehensively summarized the pharmacological activities and pharmacokinetics of STS, which could support the further application and development of STS. In the recent decades, numerous experimental and clinical studies have been conducted to investigate the potential treatment effects of STS in various diseases, such as heart diseases, brain diseases, pulmonary diseases, cancers, sepsis and so on. The underlying mechanisms were most related to anti-oxidative and anti-inflammatory effects of STS via regulating various transcription factors, such as NF-κB, Nrf2, Stat1/3, Smad2/3, Hif-1α and β-catenin. Iron channels, including Ca2+, K+ and Cl- channels, were also the important targets of STS. Additionally, we emphasized the differences between STS and Tan IIA despite the interchangeable use of Tan IIA and STS in many previous studies. It is promising to improve the efficacy and reduce side effects of chemotherapeutic drug by the combination use of STS in canner treatment. The application of STS in pregnancy needs to be seriously considered. Moreover, the drug-drug interactions between STS and other drugs needs to be further studied as well as the complications of STS.

Copyright © 2019. Published by Elsevier Masson SAS.

KEYWORDS

Apoptosis; Cardiovascular disease; Inflammation; Iron channel; Neoplasms; Oxidative stress; Sodium tanshinone IIA sulfonate; Traditional Chinese medicine; Transcription factor

Title

Sodium tanshinone IIA sulfonate: A review of pharmacological activity and pharmacokinetics.

Author

Zhou ZY1, Zhao WR2, Zhang J3, Chen XL4, Tang JY5.

Publish date

2019 Oct

PMID

31132732

Abstract

Our study aimed to determine the effects of sodium tanshinone IIA sulfonate (STS) on proliferation, migration, invasion, and inflammation in rheumatoid arthritis human fibroblast-like synoviocytes (RA-HFLSs). Firstly, results demonstrated STS reduced proliferation, migration, invasion in HFLSs. Also, we found that STS could alleviate the reorganizations of F-actin cytoskeleton in TNF-α-treated HFLSs. In addition, STS decreased the production of IL-1β, IL-6, MMP-1, and MMP-3 in TNF-α-treated RA-HFLSs. Further study showed that STS blocked MAPK/NF-κB activations in TNF-α-stimulated RA-HFLSs. Moreover, we illustrated that STS could alleviate rheumatoid arthritis progression and prevent inflammation damage in joint tissues of collagen-induced arthritis (CIA) mice. Taken together, this study suggested that STS inhibited proliferation, migration, invasion, and inflammation of RA-HFLSs by blocking MAPK/NF-κB pathways.

Copyright © 2019 Elsevier B.V. All rights reserved.

KEYWORDS

Fibroblast-like synoviocytes rheumatoid arthritis; Inflammation; MAPK/NF-κB pathway; Migration; Proliferation; Sodium tanshinone IIA sulfonate

Title

Sodium tanshinone IIA sulfonate inhibits proliferation, migration, invasion and inflammation in rheumatoid arthritis fibroblast-like synoviocytes.

Author

Wang Z1, Li J1, Zhang J1, Xie X2.

Publish date

2019 Aug

PMID

31051158

Abstract

Tanshinone ⅡA Sodium Sulfonate (DS-201), a derivative of traditional Chinese medicinal herb Danshen, has been clinically used for various cardiovascular diseases. Previous studies showed that DS-201 induced vascular relaxation partly due to the activation of the large conductance Ca2+-activated potassium (BKCa) channels. However, the efficacy of DS-201 on the resistant vessels in hypertension remains unknown. Mesentery arteries obtained from spontaneously hypertensive rats (SHR) and hypertension patients were used in this study. The endothelium-denuded mesenteric arteries were prepared to measure the artery tension and evaluate the vasodilatory effect of DS-201. The results showed that DS-201 had a vasodilatory effect on the mesenteric artery rings pre-contracted with either phenylephrine (PE) or thromboxane mimetic U46619 in a concentration-dependent manner. However, the vasodilatory effect of DS-201 significantly decreased in hypertension than in control arteries due to a decrease in protein level of BKCa β1subunit. A BKCa channel blocker IbTX (200 nM) significantly inhibited the relaxant effect of DS-201 on non-hypertensive arteries, whereas the BKCa channel specific agonist NS1619 rescued the vasodilating effects of DS-201 on hypertensive vessels. These results indicate that the vasodilating effect of DS-201 is BKCa-dependent. This study demonstrated that DS-201 alone may not be effective for treating hypertension, but it may be considered as therapy combined with BKCa-agonists or methods rescuing BKCa functions.

Copyright © 2019. Published by Elsevier B.V.

KEYWORDS

A sodium sulfonate (DS-201); Hypertension; Large conductance Ca(2+)-activated potassium (BK(Ca)) channels; Mesenteric artery; Tanshinone Ⅱ; Vasodilation

Title

Decreased vasodilatory effect of Tanshinone ⅡA Sodium Sulfonate on mesenteric artery in hypertension.

Author

Zhou Y1, Liu X1, Zhang X1, Wen J1, Cheng J1, Li P1, Wang N1, Zhou X1, Xia D2, Yang Q2, Yang Y3.

Publish date

2019 Jul


Description :

Tanshinone IIA sulfonate (sodium) is a water-soluble derivative of tanshinone IIA, which acts as an inhibitor of store-operated Ca2+ entry (SOCE), and is used to treat cardiovascular disorders.