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Tanshinone IIA

$43

  • Brand : BIOFRON

  • Catalogue Number : BF-T3008

  • Specification : 98%

  • CAS number : 568-72-9

  • Formula : C19H18O3

  • Molecular Weight : 294.33

  • PUBCHEM ID : 164676

  • Volume : 25mg

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Catalogue Number

BF-T3008

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

294.33

Appearance

Red crystals

Botanical Source

Salvia miltiorrhiza,Aquilaria sinensis,Salvia bowleyana

Structure Type

Terpenoids

Category

Standards;Natural Pytochemical;API

SMILES

CC1=COC2=C1C(=O)C(=O)C3=C2C=CC4=C3CCCC4(C)C

Synonyms

Phenanthro[1,2-b]furan-10,11-dione, 6,7,8,9-tetrahydro-1,6,6-trimethyl-/Tanshinone IIA/tanshinone II-A/Dan Shen Ketone/Tanshionesiia/Tanshine II/TANSHION P.E/1,6,6-Trimethyl-6,7,8,9-tetrahydrophenanthro[1,2-b]furan-10,11-dione/SweetOrange/QS-D-77-4-2/TANSHINONE A/tanshiones/Tanshinone II/TANSHINONES IIA

IUPAC Name

1,6,6-trimethyl-8,9-dihydro-7H-naphtho[1,2-g][1]benzofuran-10,11-dione

Density

1.2±0.1 g/cm3

Solubility

Methanol; Acetone

Flash Point

236.4±21.1 °C

Boiling Point

480.7±44.0 °C at 760 mmHg

Melting Point

205-207ºC

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

2932990000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:568-72-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

28953247

Abstract

Tanshinone IIA is a diterpene quinone isolated from the roots of Salviamiltiorrhiza bunge that has traditionally been used in China for the treatment of cardiovascular and cerebrovascular disorders. Although there is recent evidence showing that tanshinone IIA has an anti-obesity effect, its underlying mechanism of anti-obesity effect is poorly understood. Here, we investigated the effect of tanshinone IIA on lipid accumulation in 3T3-L1 preadipocytes and zebrafish. Notably, tanshinone IIA at 10 μM concentration greatly reduced lipid accumulation and triglyceride (TG) contents during 3T3-L1 preadipocyte differentiation, suggesting its anti-adipogenic effect. On mechanistic levels, tanshinone IIA reduced the expression levels of CCAAT/enhancer-binding protein-α (C/EBP-α), peroxisome proliferator-activated receptor-γ (PPAR-γ), fatty acid synthase (FAS), and perilipin A but also the phosphorylation levels of signal transducer and activator of transcription-3/5 (STAT-3/5) in differentiating 3T3-L1 cells. In addition, tanshinone IIA strongly inhibited leptin and resistin mRNA expression in differentiating 3T3-L1 cells. Importantly, the tanshinone IIA’s lipid-reducing effect was also seen in zebrafish. In sum, these findings demonstrate that tanshinone IIA has anti-adipogenic effects on 3T3-L1 cells and zebrafish, and its anti-adipogenic effect on 3T3-L1 cells is largely attributable to the reduced expression and/or phosphorylation levels of C/EBP-α, PPAR-γ, FAS, perilipin A, and STAT-3/5.

KEYWORDS

3T3-L1; adipogenesis; tanshinone IIA; zebrafish

Title

Anti-Adipogenic Effects on 3T3-L1 Cells and Zebrafish by Tanshinone IIA.

Author

Park YK1, Obiang-Obounou BW2, Lee J3, Lee TY4, Bae MA5, Hwang KS6, Lee KB7, Choi JS8, Jang BC9.

Publish date

2017 Sep 27

PMID

29763899

Abstract

BACKGROUND/AIMS:
Tanshinone IIA is a chemical compound extracted from Salvia miltiorrhiza Bunge, a perennial plant also known as red sage used in traditional Chinese medicine. Tanshinone IIA has been shown to protect against various organ injuries. In this study, we hypothesized that Tanshinone IIA could play an anti-oxidative role in contrast-induced nephropathy (CIN) through enhancing Nrf2/ARE activation.

METHODS:
To test whether Tanshinone IIA can attenuate CIN, oxidative stress, and apoptosis, we utilized two models: an in vivo Sprague-Dawley rat model of ioversol-induced CIN and an in vitro cell model of oxidative stress in which HK2 cells, a human renal tubular cell line, are treated with hydrogen peroxide (H2O2). Rats were randomly assigned to 4 groups (n = 6 per group): control group, ioversol group (ioversol-induced CIN), vehicle group (ioversol-induced CIN rats pretreated with vehicle), and Tanshinone IIA group (ioversol-induced CIN rats pretreated with 25mg/kg Tanshinone IIA). Renal functions, renal injuries and apoptosis were evaluated by using serum creatinine, histological scoring, and TUNEL staning respectively. Malondialdehyde, 8-hydroxy-2′ -deoxyguanosine, and intracellular reactive oxygen species were used for oxidative stress assessment. Levels of Nrf2 and heme oxygenase-1 (HO-1) were measured in vivo and in vitro.

RESULTS:
Tanshinone IIA attenuated renal tubular necrosis, apoptosis and oxidative stress in rats and oxidative stress in HK2 cells. Furthermore, Tanshinone IIA activated Nrf2, and up-regulated HO-1 expression in vivo and in vitro, resulting in a reduction in oxidative stress.

CONCLUSION:
Tanshinone IIA may protect against CIN through enhancing Nrf2/ARE activation.

© 2018 The Author(s). Published by S. Karger AG, Basel.

KEYWORDS

Contrast-induced nephropathy; Nrf2; Oxidative stress; Tanshinone IIA

Title

Tanshinone IIA Attenuates Contrast-Induced Nephropathy via Nrf2 Activation in Rats.

Author

Liang R1, Zhao Q2, Jian G1, Cheng D1, Wang N1, Zhang G3, Wang F3.

Publish date

2018

PMID

29943422

Abstract

OBJECTIVES:
To explore the potential therapeutic effect of Tanshinone IIA against ovarian cancer in vitro and elucidate the underlying molecular mechanism.

METHODS:
The cell survival upon Tanshinone IIA treatment was determined by the clonogenic assay. Cell apoptosis was analysed by Annexin V/propidium iodide double staining. The cleaved caspase-3/poly ADP-ribose polymerase and apoptosis-related factors were quantified by Western blotting. The relative expression of microRNAs (miRs) was determined by real-time polymerase chain reaction.

KEY FINDINGS:
Tanshinone IIA treatment induced significant apoptosis in TOV-21G cells. Tanshinone suppressed survivin expression while not affected Bax, Bcl-2 and Bcl-xL. We further predicted and experimentally confirmed overexpression of miR-205 in TOV-21G, which ectopic significantly inhibited survivin and promoted cell apoptosis. miR-205-specific antagonist completely abrogated the cell suppressive effect of Tanshinone IIA.

CONCLUSIONS:
Our data suggested that Tanshinone IIA induced cell apoptosis in ovarian carcinoma TOV-21G cells via direct upregulation of miR-205. Our study highlighted the potential therapeutic application of Tanshinone IIA against ovarian malignancy.

© 2018 Royal Pharmaceutical Society.

KEYWORDS

Tanshinone IIA; microRNA-205; ovarian carcinoma; survivin

Title

Tanshinone IIA effects on ovarian cancer cell line.

Author

Li N1, Yang L2, Zhang B3, Chen S1

Publish date

2018 Oct


Description :

Tanshinone IIA (Tan IIA) is one of the main fat-soluble compositions in the root of red-rooted salvia. Tanshinone IIA may suppress angiogenesis by targeting the protein kinase domains of VEGF/VEGFR2.