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    • Tetrahydroxyxanthone

    $258

    Brand : BIOFRON
    Catalogue Number : AV-H17100
    Specification : 98%
    CAS number : 2980-32-7
    Formula : C13H8O6
    Molecular Weight : 260.2
    PUBCHEM ID : 5281626
    Volume : 20mg

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    Catalogue Number

    AV-H17100

    Analysis Method

    HPLC,NMR,MS

    Specification

    98%

    Storage

    2-8°C

    Molecular Weight

    260.2

    Appearance

    Yellow crystalline powder

    Botanical Source

    Gentiana bellidifolia and of Swertia spp.

    Structure Type

    Category

    Standards;Natural Pytochemical;API

    SMILES

    C1=CC(=C2C(=C1O)C(=O)C3=C(C=C(C=C3O2)O)O)O

    Synonyms

    Demethylbellidifolin/Xanthen-9-one,1,3,5,8-tetrahydroxy/Desmethylbellidifolin/Bellidin/norbellidifolin/1,3,5,8-tetrahydroxyxanthone/Desmethybellidifolin/norbellidifodin/1,3,5,8-Tetrahydroxy-9H-xanthen-9-one/9H-Xanthen-9-one, 1,3,5,8-tetrahydroxy-/1,3,5,8-tetrahydroxy-xanthen-9-one/1,3,5,8-tetrahydroxyxanthen-9-one

    IUPAC Name

    1,3,5,8-tetrahydroxyxanthen-9-one

    Density

    1.8±0.1 g/cm3

    Solubility

    Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

    Flash Point

    242.0±25.0 °C

    Boiling Point

    605.6±55.0 °C at 760 mmHg

    Melting Point

    317ºC

    InChl

    InChI=1S/C13H8O6/c14-5-3-8(17)10-9(4-5)19-13-7(16)2-1-6(15)11(13)12(10)18/h1-4,14-17H

    InChl Key

    MPXAWSABMVLIBU-UHFFFAOYSA-N

    WGK Germany

    RID/ADR

    HS Code Reference

    Personal Projective Equipment

    Correct Usage

    For Reference Standard and R&D, Not for Human Use Directly.

    Meta Tag

    provides coniferyl ferulate(CAS#:2980-32-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

    No Technical Documents Available For This Product.

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    PMID

    29997352

    Abstract
    This study used the 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl 3-oxide radical (PTIO?) trapping model to study the antioxidant activities of 16 natural xanthones in aqueous solution, including garcinone C, γ-mangostin, subelliptenone G, mangiferin, 1,6,7-trihydroxy-xanthone, 1,2,5-trihydroxyxanthone, 1,5,6-trihydroxyxanthone, norathyriol, 1,3,5,6-tetrahydroxy-xanthone, isojacareubin, 1,3,5,8-tetrahydroxyxanthone, isomangiferin, 2-hydroxyxanthone, 7-O-methylmangiferin, neomangiferin, and lancerin. It was observed that most of the 16 xanthones could scavenge the PTIO? radical in a dose-dependent manner at pH 4.5 and 7.4. Among them, 12 xanthones of the para-di-OHs (or ortho-di-OHs) type always exhibited lower half maximal inhibitory concentration (IC50) values than those not of the para-di-OHs (or ortho-di-OHs) type. Ultra-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry (UPLC-ESI-Q-TOF-MS/MS) analysis revealed that most of these xanthones gave xanthone-xanthone dimers after incubation with PTIO?, except for neomangiferin. Based on these data, we concluded that the antioxidant activity of phenolic xanthone may be mediated by electron-transfer (ET) plus H+-transfer mechanisms. Through these mechanisms, some xanthones can further dimerize unless they bear huge substituents with steric hindrance. Four substituent types (i.e., para-di-OHs, 5,6-di-OHs, 6,7-di-OHs, and 7,8-di-OHs) dominate the antioxidant activity of phenolic xanthones, while other substituents (including isoprenyl and 3-hydroxy-3-methylbutyl substituents) play a minor role as long as they do not break the above four types.
    KEYWORDS

    xanthone, structure-activity relationship, antioxidant, ortho-di-OHs, para-di-OHs

    Title

    2-Phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl 3-oxide Radical (PTIO?) Trapping Activity and Mechanisms of 16 Phenolic Xanthones

    Author

    Xican Li,1,2,*† Ban Chen,1,2,† Xiaojun Zhao,1,2 and Dongfeng Chen3,4,*

    Publish date

    2018 Jul;

    PMID

    30258745

    Abstract
    The structure-activity relationships of 31 xanthones were analyzed by using the ferric reducing antioxidant power (FRAP) assay to determine their electron?transfer (ET) potential. It was proven that the ET potential of xanthones was dominated by four moieties (i.e. hydroquinone moiety, 5,6?catechol moiety, 6,7?catechol moiety, and 7,8?catechol moiety) and was only slightly affected by other structural features, including a single phenolic OH group, the resorcinol moiety, the transannular dihydroxy moiety, a methoxy group, a sugar residue, an isoprenyl group, a cyclized isoprenyl group, and an isopentanol group. The results could be used to predict the ET potentials of other antioxidant xanthones.
    KEYWORDS

    antioxidants, electron transfer, fused-ring systems, structure-activity relationships, xanthones

    Title

    Structure-Activity Relationship and Prediction of the Electron?Transfer Potential of the Xanthones Series

    Author

    Prof. Xican Li,corresponding author 1 , 2 Qian Jiang, 1 , 2 Ban Chen, 1 , 2 Xiaoling Luo, 1 and Prof. Dongfeng Chencorresponding author 3 , 4

    Publish date

    2018 Sep;