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Theophylline

$43

  • Brand : BIOFRON

  • Catalogue Number : BF-T3006

  • Specification : 98%

  • CAS number : 58-55-9

  • Formula : C7H8N4O2

  • Molecular Weight : 180.16

  • PUBCHEM ID : 2153

  • Volume : 100mg

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Catalogue Number

BF-T3006

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

180.16

Appearance

White crystalline powder

Botanical Source

Camellia sinensis

Structure Type

Nucleosiede

Category

Standards;Natural Pytochemical;API

SMILES

CN1C2=C(C(=O)N(C1=O)C)NC=N2

Synonyms

Xanthium/LABID/Elixex/Theotard/duraphy/Theolair/1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-/Slo-PhyllinTM/Theoclear/Teonova/Theon/[13C]-Theophyllin/Egifilin/X 115/Cetraphylline/Duraphyllin/Adisne/Theobid/Teosona/1,3-Dimethylxanthine/Theophylline/1,3-Dimethyl-3,7-dihydro-1H-purine-2,6-dione/Etheophyl/Euphylong/austyn/Diffumal/Nuelin/Talotren/Theodel/Solosin/Elixophyllin/Pulmidur/Theoplus/Afonilum/Pulmo-Timelets/[14C]-Theophyllin/Diphyllin (VAN)/LASMA/Physpan/Unifyl/3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione/Bronchoretard/accurb/Slo-PhyllinThealTheona PEuphyllineBilordylunidur1,3-Dimethylpurine-2,6(1H,3H)-dioneUniphylTheodrip[3H]-TheophyllinUNIPHYLLINasmaxAerolate

IUPAC Name

1,3-dimethyl-7H-purine-2,6-dione

Density

1.5±0.1 g/cm3

Solubility

Methanol

Flash Point

228.4±26.5 °C

Boiling Point

454.1±37.0 °C at 760 mmHg

Melting Point

271-273 °C

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

2939590000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:58-55-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

9378066

Title

[Theophylline].

Author

Staib AH1, Fuhr U.

Publish date

1997 Oct 17

PMID

32001318

Abstract

Theophylline is a kind of methyl xanthine, which has been suggested to inhibit the activity of phosphodiesterase and increase the intracellular level of cyclic adenine monophosphate (cAMP). Theophylline has also been reported to increase the length and complexity of the dendritic process in melanocytes. However, the mode of action of theophylline in melanogenesis has never been reported. In this study, the effects of theophylline on melanogenesis were evaluated spectrophotometrically by the mushroom tyrosinase activity assay and by the determination of the intracellular tyrosinase activity and melanin content. The expression levels of melanogenesis-related proteins were analyzed by Western blot. The results indicated that theophylline (100-500 μM) effectively enhanced melanogenesis in the B16F10 murine melanoma cells. Moreover, theophylline increased the protein expression levels of microphthalmia-associated transcription factor (MITF), tyrosinase, and tyrosinase-related protein 1 (TRP-1), and the level of phosphorylated extracellular regulated protein kinase (p-ERK) and phosphorylated glycogen synthase kinase-3β (p-GSK3β) were also increased. In summary, the results revealed that theophylline promoted melanogenesis in B16F10 cells by upregulating the mitogen-activated protein kinase kinase 1 (MEK 1/2) and Wnt/β-catenin signaling pathways.

Copyright © 2020 Elsevier Ltd. All rights reserved.

KEYWORDS

MEK 1/2; MITF; Theophylline; Tyrosinase; Wnt/β-catenin

Title

Theophylline enhances melanogenesis in B16F10 murine melanoma cells through the activation of the MEK 1/2, and Wnt/β-catenin signaling pathways.

Author

Huang HC1, Yen H2, Lu JY3, Chang TM4, Hii CH5.

Publish date

2020 Mar

PMID

31972440

Abstract

This study was aimed at investigating the effect of grewia polysaccharides on the mechanical and release properties of tablet matrices containing binary mixtures of the polysaccharide with psyllium. Two grades of grewia polysaccharides (GG and GDS) were extracted and binary mixtures of the polysaccharides with psyllium were formulated into tablet matrices containing theophylline as the model drug. The true, bulk and tapped densities, Carr’s compressibility index of the powders and binary composites were determined before tablet compression. Tablet properties (hardness, porosity, and drug release from the matrices) were investigated. The dissolution test was carried out in 0.1 M HCl (pH 1.2) and phosphate buffer (pH 6.8). The results show that GG and GDS produced tablets with good mechanical strength (108.33 N and 95.70 N, respectively) while psyllium produced softer tablets (7.13 N). The combination of psyllium and grewia polysaccharides in the matrices resulted in a significant increase in the mechanical strength of the matrices when compared to matrices containing psyllium alone as the matrix former. The results also showed that GG and GDS reduced the dissolution rate and effectively eliminated the burst release of theophylline from the psyllium matrices at both pHs. The matrices of GG or GDS and the binary mixtures conform to non-Fickian anomalous diffusion with n > 0.45. When overcoming the burst release of drug from matrices such as psyllium, grewia polysaccharides may provide an effective reduction and a more sustained drug release from such matrices.

Copyright © 2020 Elsevier B.V. All rights reserved.

KEYWORDS

Grewia polysaccharides; Matrices; Psyllium gum; Release behaviour; Theophylline

Title

Mechanical and release behaviour of theophylline from matrix tablets containing psyllium powder in combination with grewia polysaccharides.

Author

Nep EI1, Kaur N2, Shaboun S3, Adebisi AO2, Smith AM2, Conway BR2, Asare-Addo K4.

Publish date

2020 Apr


Description :

Theophylline is a nonselective phosphodiesterase (PDE) inhibitor, adenosine receptor blocker, and histone deacetylase (HDAC) activator.