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Thevetiaflavone

$1,280

  • Brand : BIOFRON

  • Catalogue Number : BN-B1459

  • Specification : 98%(HPLC)

  • CAS number : 29376-68-9

  • Formula : C16H12O5 

  • Molecular Weight : 284.3

  • PUBCHEM ID : 5315202

  • Volume : 5mg

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Catalogue Number

BN-B1459

Analysis Method

Specification

98%(HPLC)

Storage

-20℃

Molecular Weight

284.3

Appearance

Yellow powder

Botanical Source

This product is isolated and purified from the herbs of Wikstroemia indica

Structure Type

Category

SMILES

COC1=CC(=CC2=C1C(=O)C=C(O2)C3=CC=C(C=C3)O)O

Synonyms

5,4'-Dimethoxy-7-hydroxy-flavon/apigenin 5-monomethyl ether/5-O-methylacacetin/7,4'-dihydroxy-5-methoxy-isoflavone/5-O-METHYLAPIGENIN/7,4'-dihydroxy-5-methoxy-flavone/4H-1-Benzopyran-4-one, 7-hydroxy-2-(4-hydroxyphenyl)-5-methoxy-/Vertiaflavone/apigenin 4',5-dimethyl ether/Apigenin 5-methyl ether/7-Hydroxy-5,4'-dimethoxy-isoflavon/7-Hydroxy-2-(4-hydroxyphenyl)-5-methoxy-4H-chromen-4-one/apigenin 5,4'-dimethyl ether/5-Methoxy-7,4'-dihydroxyflavon/Thevetiaflavone/5-methoxy-7,4'-dihydroxyflavone

IUPAC Name

Density

1.4±0.1 g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

218.3±23.6 °C

Boiling Point

567.9±50.0 °C at 760 mmHg

Melting Point

263℃

InChl

InChl Key

YQABHAHJGSNVQR-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:29376-68-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

28990067

Abstract

Cerebral ischemia and following reperfusion affects many people worldwide. To discover efficient therapeutic approaches, numerous natural products have been investigated. The current study investigated the protective effects of thevetiaflavone, a natural flavonoid obtained from Wikstroemia indica, and the associated mechanisms using PC12 cells induced by oxygen and glucose deprivation. As a result, thevetiaflavone improves cell viability and suppresses the leakage of lactate dehydrogenase from the cytoplasm. Further investigation of the mechanisms demonstrated that thevetiaflavone decreases overproduction of ROS and ameliorates ROS‑mediated mitochondrial dysfunction, including collapse of mitochondrial membrane potential and mitochondrial permeability transition pore opening. Thevetiaflavone reduces the intracellular Ca2+ level, which is closely associated with mitochondrial function and interplays with ROS. Furthermore, thevetiaflavone inhibits apoptosis in PC12 cells through upregulating the expression of Bcl‑2 and downregulating that of Bax and caspase‑3 in addition to increasing the activity of caspase‑3. These results further indicate the protective effects of thevetiaflavone in vivo and its application in the clinic.

Title

Thevetiaflavone from Wikstroemia indica ameliorates PC12 cells injury induced by OGD/R via improving ROS‑mediated mitochondrial dysfunction.

Author

Yao H1, Yuan Z2, Wei G3, Chen C1, Duan J1, Li Y1, Wang Y3, Zhang C1, Liu Y3.

Publish date

2017 Dec


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