Catalogue Number
BN-B1459
Analysis Method
Specification
98%(HPLC)
Storage
-20℃
Molecular Weight
284.3
Appearance
Yellow powder
Botanical Source
This product is isolated and purified from the herbs of Wikstroemia indica
Structure Type
Category
SMILES
COC1=CC(=CC2=C1C(=O)C=C(O2)C3=CC=C(C=C3)O)O
Synonyms
5,4'-Dimethoxy-7-hydroxy-flavon/apigenin 5-monomethyl ether/5-O-methylacacetin/7,4'-dihydroxy-5-methoxy-isoflavone/5-O-METHYLAPIGENIN/7,4'-dihydroxy-5-methoxy-flavone/4H-1-Benzopyran-4-one, 7-hydroxy-2-(4-hydroxyphenyl)-5-methoxy-/Vertiaflavone/apigenin 4',5-dimethyl ether/Apigenin 5-methyl ether/7-Hydroxy-5,4'-dimethoxy-isoflavon/7-Hydroxy-2-(4-hydroxyphenyl)-5-methoxy-4H-chromen-4-one/apigenin 5,4'-dimethyl ether/5-Methoxy-7,4'-dihydroxyflavon/Thevetiaflavone/5-methoxy-7,4'-dihydroxyflavone
IUPAC Name
Density
1.4±0.1 g/cm3
Solubility
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Flash Point
218.3±23.6 °C
Boiling Point
567.9±50.0 °C at 760 mmHg
Melting Point
263℃
InChl
InChl Key
YQABHAHJGSNVQR-UHFFFAOYSA-N
WGK Germany
RID/ADR
HS Code Reference
Personal Projective Equipment
Correct Usage
For Reference Standard and R&D, Not for Human Use Directly.
Meta Tag
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No Technical Documents Available For This Product.
28990067
Cerebral ischemia and following reperfusion affects many people worldwide. To discover efficient therapeutic approaches, numerous natural products have been investigated. The current study investigated the protective effects of thevetiaflavone, a natural flavonoid obtained from Wikstroemia indica, and the associated mechanisms using PC12 cells induced by oxygen and glucose deprivation. As a result, thevetiaflavone improves cell viability and suppresses the leakage of lactate dehydrogenase from the cytoplasm. Further investigation of the mechanisms demonstrated that thevetiaflavone decreases overproduction of ROS and ameliorates ROS‑mediated mitochondrial dysfunction, including collapse of mitochondrial membrane potential and mitochondrial permeability transition pore opening. Thevetiaflavone reduces the intracellular Ca2+ level, which is closely associated with mitochondrial function and interplays with ROS. Furthermore, thevetiaflavone inhibits apoptosis in PC12 cells through upregulating the expression of Bcl‑2 and downregulating that of Bax and caspase‑3 in addition to increasing the activity of caspase‑3. These results further indicate the protective effects of thevetiaflavone in vivo and its application in the clinic.
Thevetiaflavone from Wikstroemia indica ameliorates PC12 cells injury induced by OGD/R via improving ROS‑mediated mitochondrial dysfunction.
Yao H1, Yuan Z2, Wei G3, Chen C1, Duan J1, Li Y1, Wang Y3, Zhang C1, Liu Y3.
2017 Dec
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