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Thymol

$43

  • Brand : BIOFRON

  • Catalogue Number : BF-T3013

  • Specification : 98%

  • CAS number : 89-83-8

  • Formula : C10H14O

  • Molecular Weight : 150.22

  • PUBCHEM ID : 6989

  • Volume : 100mg

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Catalogue Number

BF-T3013

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

150.22

Appearance

White crystalline powder

Botanical Source

Duhaldea nervosa

Structure Type

Phenolics

Category

Standards;Natural Pytochemical;API

SMILES

CC1=CC(=C(C=C1)C(C)C)O

Synonyms

6-Isopropyl-3-methylphenol/6-Isopropyl-m-cresol/3-methyl-6-isopropyl-phenol/5-methyl-2-(propan-2-yl)phenol/Thyme camphor/Phenol, 5-methyl-2-(1-methylethyl)-/2-isopropyl-5-methylphenol/5-methyl-2-(1-methylethyl)phenol/1-methyl-4-isopropyl-3-hydroxybenzene/Isopropyl cresol/3-p-Cymenol/5-methyl-2-propan-2-ylphenol/THYMOL/2-Isopropyl-5-methyl-phenol/Thymic acid/5-Methyl-2-isopropylphenol/1-hydroxy-2-isopropyl-5-methylbenzene

IUPAC Name

5-methyl-2-propan-2-ylphenol

Density

1.0±0.1 g/cm3

Solubility

Methanol

Flash Point

102.2±0.0 °C

Boiling Point

233.0±0.0 °C at 760 mmHg

Melting Point

48-51 °C(lit.)

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

2907190000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:89-83-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

27211664

Abstract

Thymol (2-isopropyl-5-methylphenol) is the main monoterpene phenol occurring in essential oils isolated from plants belonging to the Lamiaceae family (Thymus, Ocimum, Origanum, and Monarda genera), and other plants such as those belonging to the Verbenaceae, Scrophulariaceae, Ranunculaceae, and Apiaceae families. These essential oils are used in the food industry for their flavouring and preservative properties, in commercial mosquito repellent formulations for their natural repellent effect, in aromatherapy, and in traditional medicine for the treatment of headaches, coughs, and diarrhea. Many different activities of thymol such as antioxidant, anti-inflammatory, local anaesthetic, antinociceptive, cicatrizing, antiseptic, and especially antibacterial and antifungal properties have been shown. This review aims to critically evaluate the available literature regarding the antibacterial and antifungal effects of thymol.

Copyright © 2016 Elsevier Ltd. All rights reserved.

KEYWORDS

Antibacterial; Antifungal; Monoterpene; Thymol; Thymus

Title

Antibacterial and antifungal activities of thymol: A brief review of the literature.

Author

Marchese A1, Orhan IE2, Daglia M3, Barbieri R1, Di Lorenzo A3, Nabavi SF4, Gortzi O5, Izadi M6, Nabavi SM7.

Publish date

2016 Nov 1

PMID

28977246

Abstract

Thymol is a monoterpene and acetylation form of this compound can reduce the toxicity and enhance its biological effects. The objective of this study was to evaluate the effect of thymol and thymol acetate (TA) on egg, larva and adult Haemonchus contortus and the cuticular changes, acute toxicity in mice and the efficacy on sheep gastrointestinal nematodes. In vitro tests results were analyzed by analysis of variance (ANOVA) and followed by comparison with Tukey test or Bonferroni. The efficacy of in vivo test was calculated by the BootStreet program. In the egg hatch test (EHT), thymol (0.5 mg/mL) and TA (4 mg/mL) inhibited larval hatching by 98% and 67.1%, respectively. Thymol and TA (8 mg/mL) inhibited 100% of larval development. Thymol and TA (800 µg/mL) reduced the motility of adult worms, by 100% and 83.4%, respectively. Thymol caused cuticular changes in adult worm teguments. In the acute toxicity test, the LD50 of thymol and TA were 1,350.9 mg/kg and 4,144.4 mg/kg, respectively. Thymol and TA reduced sheep egg count per gram of faeces (epg) by 59.8% and 76.2%, respectively. In in vitro tests thymol presented better anthelmintic activity than TA. However TA was less toxic and in in vivo test efficacy was similar.

Title

Anthelmintic effect of thymol and thymol acetate on sheep gastrointestinal nematodes and their toxicity in mice.

Author

Andre WPP1, Cavalcante GS1, Ribeiro WLC1, Santos JMLD1, Macedo ITF1, Paula HCB2, Morais SM1, Melo JV3, Bevilaqua CML1.

Publish date

2017 Jul-Sep

PMID

32201813

Abstract

The monoterpene thymol has been proposed as a valuable alternative to in-feed antibiotics in animal production. However, the effectiveness of the antimicrobial is comprised by its fast absorption in the upper gastrointestinal tract. In this work, two glucoconjugates, thymol α-d-glucopyranoside (TαG) and thymol β-d-glucopyranoside (TβG), were compared with free thymol for their potential to deliver higher concentrations of the active compound to the distal small intestine of supplemented piglets. Additionally, an analytical method was developed and validated for the simultaneous quantification of thymol and its glucoconjugates in different matrices. In stomach contents of pigs fed with 3333 μmol kg-1 thymol, TαG, or TβG, total thymol concentrations amounted to 3048, 2357, and 1820 μmol kg-1 dry matter, respectively. In glucoconjugate-fed pigs, over 30% of this concentration was present in the unconjugated form, suggesting partial hydrolysis in the stomach. No quantifiable levels of thymol or glucoconjugates were detected in the small intestine or cecum for any treatment, indicating that conjugation with one glucose unit did not sufficiently protect thymol from early absorption.

Copyright © 2020 American Chemical Society.

Title

Fate of Thymol and Its Monoglucosides in the Gastrointestinal Tract of Piglets.

Author

Van Noten N1, Van Liefferinge E1, Degroote J1, De Smet S1, Desmet T2, Michiels J1.

Publish date

2020 Mar 9


Description :

Thymol is the main monoterpene phenol occurring in essential oils isolated from plants belonging to the Lamiaceae family, and other plants such as those belonging to the Verbenaceae, Scrophulariaceae, Ranunculaceae and Apiaceae families. Thymol has antioxidant, anti-inflammatory, antibacterial and antifungal effects[1].