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Toosendanin

$395

  • Brand : BIOFRON

  • Catalogue Number : BF-T1006

  • Specification : 98%

  • CAS number : 58812-37-6

  • Formula : C30H38O11

  • Molecular Weight : 574.62

  • PUBCHEM ID : 9851101

  • Volume : 20mg

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Quantity
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Catalogue Number

BF-T1006

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

574.62

Appearance

White crystalline powder

Botanical Source

Melia azedarach

Structure Type

Terpenoids

Category

Standards;Natural Pytochemical;API

SMILES

CC(=O)OC1CC(C23COC(C1(C2CC(C4(C3C(=O)C(C5(C46C(O6)CC5C7=COC=C7)C)OC(=O)C)C)O)C)O)O

Synonyms

Toosendanin/(1S,2R,4R,5R,6S,8R,10S,11S,12R,14R,15R,16R,19S,21R)-6-(3-Furyl)-12,16,19-trihydroxy-5,11,15-trimethyl-3-oxo-9,17-dioxahexacyclo[13.3.3.0.0.0.0]henicosane-4,21-diyl diacetate/3H-4,11b-propano-1H-oxireno[1',5']cyclopenta[1',2':5,6]naphtho[1,2-c]pyran-11(9H)-one, 10,14-bis(acetyloxy)-9-(3-furanyl)decahydro-3,6,12-trihydroxy-4,6a,9a-trimethyl-, (3R,4R,4aR,6R,6aS,6bS,7aR,9R,9aR,10R,11aR,11bS,12S,14R)-/3H-4,11b-Propano-1H-oxireno[1',5']cyclopenta[1',2':5,6]naphtho[1,2-c]pyran-11(9H)-one, 10,14-bis(acetyloxy)-9-(3-furanyl)decahydro-3,6,12-trihydroxy-4,6a,9a-trimethyl-, (3R,4aR,6R,6aS,6bS,7aR,9S,9aR,10R,11aR,11bS,12S,14R)-/(1S,2R,4R,5R,6S,8R,10S,11S,12R,14R,16R,19S,21R)-6-(3-Furyl)-12,16,19-trihydroxy-5,11,15-trimethyl-3-oxo-9,17-dioxahexacyclo[13.3.3.0.0.0.0]henicosane-4,21-diyl diacetate/3H-4,11b-Propano-1H-oxireno[1',5']cyclopenta[1',2':5,6]naphtho[1,2-c]pyran-11(9H)-one, 10,14-bis(acetyloxy)-9-(3-furanyl)decahydro-3,6,12-trihydroxy-4,6a,9a-trimethyl-, (3R,4R,4aR,6R,6aS,6bS,7aR,9S,9aR,10R,11aR,11bS,12S,14R)-

IUPAC Name

[(1S,2R,4R,5R,6S,8R,10S,11S,12R,14R,15R,16R,19S,21R)-4-acetyloxy-6-(furan-3-yl)-12,16,19-trihydroxy-5,11,15-trimethyl-3-oxo-9,17-dioxahexacyclo[13.3.3.01,14.02,11.05,10.08,10]henicosan-21-yl] acetate

Applications

Toosendanin, a triterpenoid extracted from the bark of fruit of Melia toosendan Sieb et Zucc, possesses analgesic, insecticidal and anti-inflammatory activities[1].

Density

1.4±0.1 g/cm3

Solubility

Methanol; Ethyl Acetate

Flash Point

385.6±32.9 °C

Boiling Point

714.0±60.0 °C at 760 mmHg

Melting Point

178-180ºC

InChl

InChI=1S/C30H38O11/c1-13(31)39-20-10-19(34)29-12-38-25(36)26(20,3)17(29)9-18(33)28(5)23(29)22(35)24(40-14(2)32)27(4)16(15-6-7-37-11-15)8-21-30(27,28)41-21/h6-7,11,16-21,23-25,33-34,36H,8-10,12H2,1-5H3/t16-,17-,18+,19-,20+,21+,23-,24-,25+,26?,27+,28+,29+,30+/m0/s1

InChl Key

NAHTXVIXCMUDLF-SLWGVJJJSA-N

WGK Germany

RID/ADR

HS Code Reference

2934990000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:58812-37-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

29861921

Abstract

Essential processes for living cells such as transcription and replication depend on the formation of specific protein-DNA recognition complexes. Proper formation of such complexes requires suitable fitting between the protein surface and the DNA surface. By adopting doxorubicin (DOX) as a model probe, we report here that Ag3 atomic quantum clusters (Ag-AQCs) inhibit the intercalation of DOX into DNA and have considerable influence on the interaction of DNA-binding proteins such as topoisomerase IV, Escherichia coli DNA gyrase and the restriction enzyme HindIII. Ag-AQCs at nanomolar concentrations inhibit enzyme activity. The inhibitory effect of Ag-AQCs is dose-dependent and occurs by intercalation into DNA. All these effects, not observed in the presence of Ag+ ions, can explain the powerful bactericidal activity of Ag-AQCs, extending the knowledge of silver bactericidal properties. Lastly, we highlight the interest of the interaction of Ag clusters with living organisms, an area that should be further explored due to the potential consequences that it might have, both beneficial and harmful.

Title

Interaction of silver atomic quantum clusters with living organisms: bactericidal effect of Ag3 clusters mediated by disruption of topoisomerase-DNA complexes†

Author

J. Neissa,a,‡ C. Perez-Arnaiz,b,‡ V. Porto,a N. Busto,b E. Borrajo,a J. M. Leal,b M. A. Lopez-Quintela,c B. Garcia,corresponding authorb and F. Dominguezcorresponding authora

Publish date

2015 Dec 1;

PMID

29218145

Abstract

Selected new fluorogenic probes that interact in different ways with Hg2+ and MeHg+ have been prepared and used for the chemical speciation of both cations in aqueous solution as well as in HEK293 cells. The best selective speciation of Hg2+ and MeHg+ has been achieved by in vitro approaches based on fluorogenic probes supported in cultured cells, due to the particular sensitivity of the HEK293 cells to permeation by Hg2+, MeHg+ and the fluorogenic probes. In particular, MeHg+ was selectively detected in cell nuclei by probe JG45.

Title

Chemical speciation of MeHg+ and Hg2+ in aqueous solution and HEK cells nuclei by means of DNA interacting fluorogenic probes†

Author

Borja Diaz de GreNu,a Jose Garcia-Calvo,a Jose Cuevas,a Gabriel Garcia-Herbosa,a BegoNa Garcia,a Natalia Busto,a Saturnino Ibeas,a Tomas Torroba,corresponding authora Blanca Torroba,b Antonio Herrera,b and Sebastian Ponscorresponding authorb

Publish date

2015 Jul 17.

PMID

26280345

Abstract

Objective
This study sought to evaluate associations between sleep time and bicycle accidents, falls under various circumstances, and dental injuries in adolescents.

Methods
A total of 61,696 participants ranging from 12 to 18 years of age who completed the Korea Youth Risk Behavior Web-based Survey (KYRBWS) in 2013 were enrolled in this study. Bicycle riding accidents were analyzed for 17,232 bicycle-riding participants. Data were collected regarding the weekday sleep duration for the most recent 7 days, which was categorized as < 5.5 h, 5.5-6.5 h, 6.5-7.5 h, or ≥ 7.5 h per day, and the incidence of bicycle accidents, slips and falls under various circumstances, and dental injuries in the most recent 12 months. Adjusted odds ratios (aORs) were calculated among sleep groups for bicycle accidents, slips and falls, and dental injuries using simple and multiple logistic regression analyses with complex sampling.

Results
Bicycle riding accidents and slips and falls in classrooms, corridors, the ground, toilets, stairs, and other unspecified situations showed positive correlations with sleep deprivation. Comparisons of groups with ≥ 7.5 h sleep, the 5.5-6.5 h group > the 6.5-7.5 h group). There was no significant relationship between sleep deprivation and dental injury.

Conclusions
This study demonstrated that sleep deprivation among Korean adolescents was associated with bicycle accidents and falls at home and school. Thus, adequate sleep may be needed to prevent accidents and falls.

Title

Sleep Deprivation Is Associated with Bicycle Accidents and Slip and Fall Injuries in Korean Adolescents

Author

So Young Kim, 1 Songyong Sim, 2 Sung-Gyun Kim, 3 and Hyo Geun Choi 4 ,*

Publish date

2015