(5S,6R,8S,8aR)-6-Hydroxy-5-(2-hydroxy-2-propanyl)-3,8-dimethyl-4,5,6,7,8,8a-hexahydro-2(1H)-azulenone/2(1H)-Azulenone, 4,5,6,7,8,8a-hexahydro-6-hydroxy-5-(1-hydroxy-1-methylethyl)-3,8-dimethyl-, (5S,6R,8S,8aR)-
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
402.0±45.0 °C at 760 mmHg
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Personal Projective Equipment
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Objective and Design
The association between healthy diet scores which reflect adherence to the US Dietary Guidelines and prevalence of nuclear cataract, assessed four to seven years later, was assessed in a sample of Women’s Health Initiative (WHI) Observational Study participants (50-79 years of age) who were residing in Iowa, Wisconsin and Oregon. Scores on the 1995 Healthy Eating Index (HEI-95), which reflect adherence to 1990 guidelines, were assigned from responses to food frequency questionnaires at WHI-baseline (1994-1998). Presence of nuclear cataract was determined from slit-lamp photographs and self-report of cataract extractions were assessed from 2001-04 in the Carotenoids in Age-Related Eye Disease Study (N=1,808).
Having a high HEI-95 score was the strongest modifiable predictor of low prevalence of nuclear cataract among numerous risk factors investigated in this sample. The multivariable-adjusted OR and 95% confidence interval for high vs. low quintile for diet score were 0.6 (0.4-0.9). Higher prevalence of nuclear cataract was also associated with other modifiable factors (smoking and marked obesity) and non-modifiable factors (having brown eyes, myopia and high pulse pressure). Vitamin supplement use was not related to cataract.
These data add to the body of evidence suggesting that eating foods that are rich in a variety of vitamins and minerals, may contribute to postponing the occurrence of the most common type of cataract in the US.
Healthy Diets and the Subsequent Prevalence of Nuclear Cataract in Women
Julie A. Mares, Rick Voland, Rachel Adler, Lesley Tinker, AE Millen, Suzen M. Moeller, Barbara Blodi, Karen M. Gehrs, Robert B. Wallace, Richard J. Chappell, Marian L. Neuhouser, G Sarto, the CAREDS Study Group
2011 Jun 1.
The government of Pakistan introduced devolution in 2001. Responsibility for delivery of most health services passed from provincial to district governments. Two national surveys examined public opinions, use, and experience of health services in 2001 and 2004, to assess the impact of devolution on these services from the point of view of the public.
A stratified random cluster sample drawn in 2001 and revisited in 2004 included households in all districts. Field teams administered a questionnaire covering views about available health services, use of government and private health services, and experience and satisfaction with the service. Focus groups in each community discussed reasons behind the findings, and district nazims (elected mayors) and administrators commented about implementation of devolution. Multivariate analysis, with an adjustment for clustering, examined changes over time, and associations with use and satisfaction with services in 2004.
Few of 57,321 households interviewed in 2002 were satisfied with available government health services (23%), with a similar satisfaction (27%) among 53,960 households in 2004. Less households used government health services in 2004 (24%) than in 2002 (29%); the decrease was significant in the most populous province. In 2004, households were more likely to use government services if they were satisfied with the services, poorer, or less educated. The majority of users of government health services were satisfied; the increase from 63% to 67% between 2002 and 2004 was significant in two provinces. Satisfaction in 2004 was higher among users of private services (87%) or private unqualified practitioners (78%). Users of government services who received all medicines from the facility or who were given an explanation of their condition were more likely to be satisfied. Focus groups explained that people avoid government health services particularly because of bad treatment from staff, and unavailable or poor quality medicines. District nazims and administrators cited problems with implementation of devolution, especially with transfer of funds.
Under devolution, the public did not experience improved government health services, but devolution was not fully implemented as intended. An ongoing social audit process could provide a basis for local and national accountability of health services.
Devolution and public perceptions and experience of health services in Pakistan: linked cross sectional surveys in 2002 and 2004
Umaira Ansari, Anne Cockcroft, Khalid Omer, Noor MD Ansari, Amir Khan, Ubaid Ullah Chaudhry, Neil Andersson
The clinical and pathological variability among patients with Alzheimer’s disease (AD) remains largely unexplained. Evidence is growing that this heterogeneity may be influenced by the heterogeneous molecular architecture of misfolded amyloid-β peptide (Aβ) in the brain. To test this hypothesis, we used unique fluorescent ligands to interrogate the molecular structure of Aβ in amyloid plaques from patients who had died with etiologically distinct subtypes of AD. We found that Aβ-amyloid plaques in the brain cluster as clouds of conformational variants that differ among certain subtypes of AD. The conformational features of AD plaques were partially transmissible to transgenic mice in a seeding paradigm, suggesting a mechanism whereby different molecular strains of Aβ propagate their features within the brain.
Alzheimer, amyloid, neurodegeneration, prion, strains
Amyloid polymorphisms constitute distinct clouds of conformational variants in different etiological subtypes of Alzheimer’s disease
Jay Rasmussen, Jasmin Mahler, Natalie Beschorner, Stephan A. Kaeser, Lisa M. Hasler, Frank Baumann, Sofie Nystrom, Erik Portelius, Kaj Blennow, Tammaryn Lashley, Nick C. Fox, Diego Sepulveda-Falla, Markus Glatzel, Adrian L. Oblak, Bernardino Ghetti, K. Peter R. Nilsson, Per Hammarstrom, Matthias Staufenbiel, Lary C. Walker, Mathias Jucker
2017 Dec 5