4,9,11-Estratrien-17b-ol-3-one/Trienolone/17-β-Trenbolone/Estra-4,9,11-trien-3-one, 17-hydroxy-, (17-β)- (9CI)/17β-hydroxy-estra-4,9,11-trien-3-one/17b-Hydroxy-19-norandrosta-4,9,11-trien-3-one/19-Norandrosta-4,9,11-trien-17b-ol-3-one/Estra-4,9,11-trien-3-one, 17-hydroxy-, (17β)-/(17β)-17-Hydroxyestra-4,9,11-trien-3-one/Trenbolone
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
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This study evaluated the sorption and transport potential of seven phototransformation products of 17α-trenbolone, 17β-trenbolone, trendione, and altrenogest, along with the parent trienone steroids in batch and column soil-water systems. In batch systems, the target solutes exhibited linear isotherms, with values for sorption coefficients (log Koc) of parent steroids (2.46-2.76) higher than those for photoproducts (1.92-2.57). In column systems, the estimated retardation factors (Rsol) for parents (2.7-5.1) were ∼2-5 times higher than those for photoproducts (0.84-1.7). The log Koc (R2 = 0.75) and Rsol (R2 = 0.89-0.98) were well correlated with measured log Kow values, indicating that hydrophobic partitioning governed the soil-solute interaction of these biologically potent compounds in soil-water systems. These data indicated that photoproducts exhibited reduced sorption affinity and increased transport potential relative to more hydrophobic parent structures. In agroecosystems, traditional runoff management practices would be expected to exhibit reduced treatment effectiveness for photoproducts relative to the parent compounds of commonly used trienone steroids.
Sorption and transport of trenbolone and altrenogest photoproducts in soil-water systems.
Yang X 1, Zhao H , Cwiertny DM , Kolodziej EP .
2019 Oct 16
Here, we developed a novel and sensitive method for the detection and quantification of metastable trenbolone and altrenogest photoproducts in agricultural receiving waters based on solid phase extraction (SPE) and liquid chromatography-tandem mass spectrometry (LC-MS/MS). Primary method analytes were seven cycloaddition or photohydration transformation products of 17α-trenbolone (17α-TBOH), 17β-trenbolone (17β-TBOH), trendione (TBO), and altrenogest (ALT), which are key contributors to the fate and environmental risks of these steroidal pharmaceuticals. Because commercial analytical standards are not available, reference standards for photoproducts were generated from trenbolone or ALT with a solar simulator (˜6 h, >10 half-lives). Efficient detection of metastable photoproducts required cold and pH neutral conditions, rapid sample processing, minimal sample storage, and consideration of cationic artifacts. Method detection limits (MDLs) were 0.034-0.40 ng L-1 for parent compounds and 0.16-2.1 ng L-1 for photoproducts, sufficient for their detection in agroecosystems. Matrix suppression was observed and corrected by internal standards, and relative recovery rates were near 100% for all analytes except for 12-OH-17α-TBOH (˜75% recovery). Intra-day variation was <20% and inter-day variation <25% for all the analytes. The developed method is capable of the analysis of trenbolone, altrenogest, and their key bioactive photoproducts in agricultural receiving waters.
Copyright © 2019 Elsevier B.V. All rights reserved
Altrenogest; LC-MS/MS; Metastable; Photoproduct; Trenbolone
Detection and quantification of metastable photoproducts of trenbolone and altrenogest using liquid chromatography-tandem mass spectrometry.
Kenyon PT1, Zhao H1, Yang X2, Wu C3, Cwiertny DM4, Kolodziej EP5.
2019 Oct 11