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Trigonelline Hydrochloride

$43

  • Brand : BIOFRON

  • Catalogue Number : BF-T3005

  • Specification : 98%

  • CAS number : 6138-41-6

  • Formula : C7H8ClNO2

  • Molecular Weight : 173.6

  • PUBCHEM ID : 134606

  • Volume : 20mg

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Catalogue Number

BF-T3005

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

173.6

Appearance

White crystalline powder

Botanical Source

Pinellia ternata,Trigonella foenum-graecum

Structure Type

Alkaloids

Category

Standards;Natural Pytochemical;API

SMILES

C[N+]1=CC=CC(=C1)C(=O)O.[Cl-]

Synonyms

Pyridinium, 3-carboxy-1-methyl-, chloride (1:1)/3-Carboxy-1-methylpyridinium chloride/Trigonelline hydroch/TRIGONELLINE HCL/trigonellinium chloride/1-Methyl-3-pyridiniumcarboxylathydrochlorid/TRIGONELLIN HYDROCHLORIDE/1-Methylpyridinium-3-carboxylate hydrochloride (1:1)/N-METHYLNICOTINIC ACID BETAINE HYDROCHLORIDE/1-Methyl-3-pyridiniumcarboxylate chlorhydrate/1-methylnicotinic acid chloride/Pyridinium, 3-carboxy-1-methyl-, chloride/N-methylpyridinium-3-carboxylate hydrochloride/1-Methyl-3-pyridiniumcarboxylate hydrochloride/Trigonelline chloride

IUPAC Name

1-methylpyridin-1-ium-3-carboxylic acid;chloride

Density

Solubility

Methanol; Water

Flash Point

Boiling Point

Melting Point

~260 °C (dec.)

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

2933390000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:6138-41-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

29936380

Abstract

Collagen is a major structural protein, with properties such as low toxicity, low immune response and promoting cellular growth. If there is an excess of collagen accumulation, especially in the myocardium it leads to fibrosis, which in turn impairs the normal functioning of the myocardial tissues. In order to overcome collagen fibrillation, trigonelline hydrochloride has been used in this study as a potential agent for inhibiting the spontaneous self-assembly of type I collagen. Trigonelline hydrochloride, a nicotinic acid derivative is largely found in Trigonella foenum-graecum L. (fenugreek). Experimental work on turbidity assay shows that there is an increase in the lag phase compared to the native collagen indicating a delay in fibrillation. According to rheological aspects, viscosity of the collagen composite decreases due to the increase in shear rate, which disentangles the aggregated particles of collagen fibrils and allows it to align along the direction of rate. Morphological assessments through AFM and HR-SEM suggest that there is an effective reduction in fibrillation with an increase in the concentration of trigonelline hydrochloride. FT-IR (ATR) studies indicate that compactness of secondary structure helicity occurs on treatment with trigonelline hydrochloride. Such promising effect of trigonelline on collagen fibrillogenesis can be judiciously used for targeting specific sites of collagen accumulation via innovative drug delivery systems.

Copyright © 2018 Elsevier B.V. All rights reserved.

KEYWORDS

Collagen type I; Fibrillogenesis; Self-assembly; Trigonelline hydrochloride

Title

Trigonelline hydrochloride: A promising inhibitor for type I collagen fibrillation.

Author

Rasheeda K1, Fathima NN2.

Publish date

2018 Oct 1


Description :

Trigonelline chloride, an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee.