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Tripterifordin

$896

Brand : BIOFRON
Catalogue Number : BD-D0222
Specification : HPLC≥98%
CAS number : 139122-81-9
Formula : C20H30O3
Molecular Weight : 318.457
PUBCHEM ID : 72369
Volume : 5mg

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Catalogue Number

BD-D0222

Analysis Method

HPLC,NMR,MS

Specification

HPLC≥98%

Storage

-20℃

Molecular Weight

318.457

Appearance

Powder

Botanical Source

Tripterygium wilfordii Hook.f.

Structure Type

Category

Standards;Natural Pytochemical;API

SMILES

CC12CCCC3(C1CCC45C3CCC(C4)C(C5)(C)O)COC2=O

Synonyms

(8α,10α,13α,16β)-16-Hydroxy-18,20-epoxykauran-18-one/(5β,8α,10α,13α,16β)-16-Hydroxy-18,20-epoxykauran-18-one/Tripterifordin

IUPAC Name

(1R,2R,5R,6R,8S,11S,12R)-6-hydroxy-6,12-dimethyl-14-oxapentacyclo[10.3.3.15,8.01,11.02,8]nonadecan-13-one

Density

1.2±0.1 g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

198.6±21.5 °C

Boiling Point

485.1±45.0 °C at 760 mmHg

Melting Point

InChl

InChI=1S/C20H30O3/c1-17-7-3-8-20(12-23-16(17)21)14(17)6-9-19-10-13(4-5-15(19)20)18(2,22)11-19/h13-15,22H,3-12H2,1-2H3/t13-,14-,15-,17-,18-,19+,20+/m1/s1

InChl Key

KLMZPLYXGZZBCX-CJSYXLNHSA-N

WGK Germany

RID/ADR

HS Code Reference

2933990000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:139122-81-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

26363489

Abstract

Tripterygium wilfordii tablet (TWT) and Tripterygium hypoglaucum tablet (THT), the preparations of the two Tripterygium herbs, are well known for the treatment of rheumatoid arthritis and other related inflammatory diseases clinically. In the present study, a high performance liquid chromatography (HPLC) coupled with electrospray ionization (ESI) tandem triple quadrupole mass spectrometry (QQQ/MS) method was developed for simultaneous quantification of 12 chemical components in Tripterygium preparations. The fragmentation patterns of analytes using ESI and collision-induced dissociation (CID) techniques were reported. This assay method was validated with respect to linearity (r(2)>0.9991), precision, repeatability, and accuracy (recovery rate between 97.2 and 104.2%). The proposed method was successfully applied for simultaneous quantification of the 12 compounds in Tripterygium preparations from the different manufactures. In addition, to evaluate the quality of Tripterygium preparations, partial least square discrimination analysis (PLS-DA) was performed to differentiate the contents of 12 compounds. In conclusion, the established HPLC/QQQ/MS method was proven to be useful and efficient for quality control of Tripterygium preparations.

Copyright © 2015 Elsevier B.V. All rights reserved.

KEYWORDS

Diterpenes; HPLC/QQQ/MS; Sesquiterpene alkaloids; Simultaneous quantification; Tripterygium preparations; Triterpenes

Title

Simultaneous determination of triptolide, tripterifordin, celastrol and nine sesquiterpene alkaloids in Tripterygium preparations using high-performance liquid chromatography-triple quadrupole mass spectrometry.

Author

Luo H1, Wu X2, Huang H3, Chen S4, Yang W2, Zhang L2, Cui H1, Yang J1, Yang A5.

Publish date

2016 Jan 5