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Uridine

$43

  • Brand : BIOFRON

  • Catalogue Number : BF-U3004

  • Specification : 98%

  • CAS number : 58-96-8

  • Formula : C9H12N2O6

  • Molecular Weight : 244.2

  • PUBCHEM ID : 6029

  • Volume : 100mg

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Catalogue Number

BF-U3004

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

244.2

Appearance

White crystalline powder

Botanical Source

Cordyceps sinensis

Structure Type

Nucleosiede

Category

Standards;Natural Pytochemical;API

SMILES

C1=CN(C(=O)NC1=O)C2C(C(C(O2)CO)O)O

Synonyms

1-β-δ-Ribofuranosyluracil/Uracil, 1-β-D-ribofuranosyl-/uracil riboside/1-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-2,4(1H,3H)-pyrimidinedione/URD/1-b-D-Ribofuranosyluracil/Uracil-1-β-D-ribofuranoside/1-b-D-Ribofuranosyl-2,4(1H,3H)-pyrimidinedione/1-(β-D-Ribofuranosyl)pyrimidin-2,4(1H,3H)-dion/NFDB2/1-β-D-Ribofuranosyl-2,4(1H,3H)-pyrimidinedione/Uridine/D-URIDINE/T6NVMVJ A- BT5OTJ CQ DQ E1Q &&β-D-Ribo Form/2(1H)-Pyrimidinone, 4-hydroxy-1-β-D-ribofuranosyl-/2,4(1H,3H)-pyrimidinedione, 1-β-D-ribofuranosyl-/4-Hydroxy-1-(β-D-ribofuranosyl)-2(1H)-pyrimidinone/Uridin/Diquafosol Impurity 11

IUPAC Name

1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione

Density

1.9±0.1 g/cm3

Solubility

Water

Flash Point

297.2±32.9 °C

Boiling Point

567.9±60.0 °C at 760 mmHg

Melting Point

163-167 °C(lit.)

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

2934990000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:58-96-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

32164840

Abstract

How gut cells distinguish between beneficial symbionts and deleterious pathobionts is a central question. In this issue of Cell Host & Microbe, Kim et al. (2020) demonstrate that the nucleoside catabolism pathway controlling bacterial uracil and ribose production is an essential trigger of the commensal to pathogen transition.

Copyright © 2020 Elsevier Inc. All rights reserved.

Title

Uridine Catabolism Breaks the Bonds of Commensalism.

Author

Joshi M1, Royet J2.

Publish date

2020 Mar 11

PMID

28277930

Abstract

Wobble uridines (U34) are generally modified in all species. U34 modifications can be essential in metazoans but are not required for viability in fungi. In this review, we provide an overview on the types of modifications and how they affect the physico-chemical properties of wobble uridines. We describe the molecular machinery required to introduce these modifications into tRNA posttranscriptionally and discuss how posttranslational regulation may affect the activity of the modifying enzymes. We highlight the activity of anticodon specific RNases that target U34 containing tRNA. Finally, we discuss how defects in wobble uridine modifications lead to phenotypes in different species. Importantly, this review will mainly focus on the cytoplasmic tRNAs of eukaryotes. A recent review has extensively covered their bacterial and mitochondrial counterparts. 1.

KEYWORDS

Anticodon wobble base; RNases; mRNA translation; protein homeostasis; stress responses; tRNA modification

Title

Wobble uridine modifications-a reason to live, a reason to die?!

Author

Schaffrath R1, Leidel SA2,3,4.

Publish date

2017 Sep 2

PMID

31993847

Abstract

OBJECTIVES:
The metabolic pathway related to uridine production was modified in Bacillus subtilis in order to increase the production of uridine.

RESULTS:
Decreasing the relative transcriptional level of pur operon in Bacillus subtilis TD300 to 80%, and the production of the derived strain TD312 was increased to 11.81 g uridine/l and the yield was increased to 270 mg uridine/g glucose. The expression of pucR gene in situ by PccpA resulting in a 194.01-fold increase in the relative transcriptional level of pucR gene and 349.71-fold increase in the relative transcriptional level of ure operon, respectively. Furthermore, the production of TD314 reached 13.06 g uridine/l, while the yield reached 250 mg uridine/g glucose.

CONCLUSION:
This is the first report that more than 13 g uridine/l with a yield of 250 mg uridine/g glucose is produced in shake flask fermentation of genetically engineered Bacillus subtilis.

KEYWORDS

Bacillus subtilis; Production; Pur operon; Ure operon; Uridine

Title

Improve uridine production by modifying related metabolic pathways in Bacillus subtilis.

Author

Zhang X1, Wang C1, Liu L1, Ban R2,3.

Publish date

2020 Apr


Description :

Uridin is a glycosylated pyrimidine-analog containing uracil attached to a ribose ring (or more specifically, aribofuranose) via a β-N1-glycosidic bond.