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Valtrate

$336

  • Brand : BIOFRON

  • Catalogue Number : BD-D1314

  • Specification : 98%(HPLC)

  • CAS number : 18296-44-1

  • Formula : C22H30O8

  • Molecular Weight : 422.47

  • PUBCHEM ID : 442436

  • Volume : 20MG

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Catalogue Number

BD-D1314

Analysis Method

HPLC,NMR,MS

Specification

98%(HPLC)

Storage

-20℃

Molecular Weight

422.47

Appearance

Yellow liquid

Botanical Source

Valeriana officinalis L./Valeriana spp. incl. Valeriana officinalis root (Radix Valerianae)

Structure Type

Iridoids

Category

Standards;Natural Pytochemical;API

SMILES

CC(C)CC(=O)OC1C=C2C(C13CO3)C(OC=C2COC(=O)C)OC(=O)CC(C)C

Synonyms

Butanoic acid, 3-methyl-, (1S,6S,7R,7aS)-4-[(acetyloxy)methyl]-6,7a-dihydrospiro[cyclopenta[c]pyran-7(1H),2'-oxirane]-1,6-diyl ester/(1S,6S,7R,7aS)-4-(Acetoxymethyl)-6,7a-dihydro-1H-spiro[cyclopenta[c]pyran-7,2'-oxirane]-1,6-diyl bis(3-methylbutanoate)/tolterodine/Baldrisedon/(1S-(1a,6a,7b,7aa))-3-Methylbutanoic Acid 4-((Acetyloxy)methyl)-6,7a-dihydrospiro(cyclopenta[c]pyran-7(1H),2'-oxirane)-1,6-diyl Ester/(1S,6S,7R,7aS)-4-[(acetyloxy)methyl]-6,7a-dihydro-1H-spiro[cyclopenta[c]pyran-7,2'-oxirane]-1,6-diyl bis(3-methylbutanoate)/valepotriate/ValtratuM/Halazuchrome B/ValepotriatuM

IUPAC Name

[(1S,6S,7R,7aS)-4-(acetyloxymethyl)-1-(3-methylbutanoyloxy)spiro[6,7a-dihydro-1H-cyclopenta[c]pyran-7,2'-oxirane]-6-yl] 3-methylbutanoate

Applications

Density

1.2±0.1 g/cm3

Solubility

Ethyl Acetate; Acetone

Flash Point

226.5±30.2 °C

Boiling Point

525.9±50.0 °C at 760 mmHg

Melting Point

InChl

InChI=1S/C22H30O8/c1-12(2)6-18(24)29-17-8-16-15(9-26-14(5)23)10-27-21(20(16)22(17)11-28-22)30-19(25)7-13(3)4/h8,10,12-13,17,20-21H,6-7,9,11H2,1-5H3/t17-,20+,21-,22+/m0/s1

InChl Key

BDIAUFOIMFAIPU-KVJIRVJXSA-N

WGK Germany

RID/ADR

HS Code Reference

2932990000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:18296-44-1) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

26006134

Abstract

A simple and selective liquid chromatography-tandem mass spectrometric method for determination of valtrate in rat plasma was developed in this study. Chromatographic separation was achieved on a Thermo BDS HYPERSIL C18 column using acetonitrile-water-formic acid (75 : 25 : 0.1, v/v/v) as mobile phase in an isocratic mode of elution at a flow rate of 300 µL/min. MS-MS detection was performed in a positive ion electrospray ionization mode with the ion transitions 445.2 → 219.2 for valtrate and 355.2 → 135.1 for internal standard (sesamin). The developed method exhibited a linear dynamic range over 5.65-1695 ng/mL for valtrate in rat plasma. The overall extraction recovery of valtrate from plasma was 86.13-88.32%. The intra- and inter-day accuracy and precision were within the pre-defined limits of ≤15% at all concentrations. The method was successfully applied to pharmacokinetic studies of valtrate in rats.

Title

Development of a LC-MS-MS Method for Quantification of Valtrate and Its Application to Pharmacokinetic Study

Author

Lichao Sun 1 , Jiqing Qiu 2 , Guangming Wang 2 , Weihong Lin 3 , Nan Zhang 1

Publish date

2015 Oct

PMID

30638055

Abstract

Valtrate is a principle compound isolated from Valeriana jatamansi Jones, a traditional Chinese folk medicine originally used to treat various nervous disorders. Here, we found that valtrate exhibited significant anti-cancer activity in vitro, especially in human breast cancer cells, while displayed relatively low cytotoxicity to normal human breast epithelial cells (MCF 10A). Valtrate induced cell cycle arrest at G2/M stage and apoptosis in MDA-MB-231 and MCF-7 cells, with reduced expression of p-Akt (Ser 473), cyclin B1 and caspase 8, and increased expression of p21, p-cdc2, cleaved-caspase 3, cleaved-caspase 7 and poly (ADP-ribose) polymerase (PARP). In addition, valtrate inhibited cell migration through down-regulation of MMP-9 and MMP-2 expression. These results demonstrate that valtrate possesses anti-breast cancer activities via cell cycle arrest, apoptosis, and inhibition of cell migration, thus supporting valtrate as a potential antitumor agent.

Title

Valtrate From Valeriana Jatamansi Jones Induces Apoptosis and Inhibits Migration of Human Breast Cancer Cells in Vitro

Author

Shasha Tian 1 , Zhizi Wang 1 , Zeqi Wu 1 , Yingying Wei 1 , Bo Yang 1 , Siyue Lou 1

Publish date

2019 Jan 12

PMID

24782906

Abstract

Valtrate is a principle compound isolated from Valeriana jatamansi Jones, which is a Traditional Chinese Medicine used to treat various mood disorders. The aim of the present study was to investigate the anxiolytic effects of valtrate in rats. The animals were orally administered valtrate (5, 10, and 20 g/kg daily) for 10 days and exposed to open field test (OFT) and elevated plus-maze (EPM). Then the corticosterone levels in the rat serum were measured by enzyme-linked immunosorbent assay (ELISA). The valtrate (10 mg/kg, p.o.) exhibited the anxiolytic effect in rats by increasing the time and entry percentage into the open arms in the EPM and the number of central entries in the OFT. Valtrate (10 mg/kg, p.o.) significantly reduced the corticosterone level in the rat serum. Taken together, these results suggest that the valtrate has anxiolytic activity in behavioral models that might be mediated via the function of hypothalamus-pituitary-adrenal axis.

Title

The Anxiolytic Effects of Valtrate in Rats Involves Changes of Corticosterone Levels

Author

Shu-Ning Shi 1 , Jin-Li Shi 1 , Yong Liu 1 , Yan-Li Wang 1 , Chun-Guo Wang 1 , Wen-Hui Hou 1 , Jian-You Guo 2

Publish date

2014