Off-white crystalline powder
4-Hydroxy-3-methoxybenzoic acid/4-hydroxy-m-Anisic acid/Benzoic acid, 4-hydroxy-3-methoxy-/4-Hydroxy-3-methoxy-benzoic acid/Vanillic acid/Acid, Vanillic
353.4±27.0 °C at 760 mmHg
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provides coniferyl ferulate(CAS#:121-34-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
Asthma is a chronic allergic ailment affecting a considerably large population of the world. The aim of this study is to evaluate the ameliorative effects of vanillic acid against ovalbumin (OVA)-induced asthma in rat model. Asthma was induced in Sprague Dawley rats and vanillic acid was orally administered at 25 and 50 mg/kg body weight for 28 days. Rats challenged with OVA showed heavy signs of airway inflammation and remodeling similar to chronic asthma, evidenced by the increased differential cell counts and presence of inflammatory cytokines in the bronchoalveolar lavage fluid (BALF), along with elevated serum immunoglobulin levels, and the histological results. However, vanillic acid dose-dependently attenuated the manifestation of OVA-induced asthma (p < 0.05) through suppression of inflammatory mediators and modulation of immunoglobulin levels in rats. The asthma mitigating properties of vanillic acid might be due to suppression of oxidative stress and prevention of lung airway inflammation.
BALF; Vanillic acid; histology; inflammatory cytokines; ovalbumine.
Vanillic Acid Mitigates the Ovalbumin (OVA)-induced Asthma in Rat Model Through Prevention of Airway Inflammation
Feng Bai 1 , Liyun Fang 2 , Huizhong Hu 2 , Yang Yang 2 , Xianxian Feng 2 , Daqing Sun 2
Serratia marcescens is one of the important nosocomial pathogens which rely on quorum sensing (QS) to regulate the production of biofilm and several virulence factors. Hence, blocking of QS has become a promising approach to quench the virulence of S. marcescens. For the first time, QS inhibitory (QSI) and antibiofilm potential of Actinidia deliciosa have been explored against S. marcescens clinical isolate (CI). A. deliciosa pulp extract significantly inhibited the virulence and biofilm production without any deleterious effect on the growth. Vanillic acid was identified as an active lead responsible for the QSI activity. Addition of vanillic acid to the growth medium significantly affected the QS regulated production of biofilm and virulence factors in a concentration dependent mode in S. marcescens CI, ATCC 14756 and MG1. Furthermore vanillic acid increased the survival of Caenorhabditis elegans upon S. marcescens infection. Proteomic analysis and mass spectrometric identification of differentially expressed proteins revealed the ability of vanillic acid to modulate the expression of proteins involved in S-layers, histidine, flagellin and fatty acid production. QSI potential of the vanillic acid observed in the current study paves the way for exploring it as a potential therapeutic candidate to treat S. marcescens infections.
Vanillic Acid From Actinidia Deliciosa Impedes Virulence in Serratia Marcescens by Affecting S-layer, Flagellin and Fatty Acid Biosynthesis Proteins
Sivasamy Sethupathy 1 , Sivagnanam Ananthi 2 , Anthonymuthu Selvaraj 1 , Balakrishnan Shanmuganathan 1 , Loganathan Vigneshwari 1 , Krishnaswamy Balamurugan 1 , Sundarasamy Mahalingam 2 , Shunmugiah Karutha Pandian 3
2017 Nov 27
Cerebral hypoperfusion induced by transient bilateral common carotid arteries occlusion (tBCCAO), is associated with deleterious alterations in several physiological parameters of the animals. This study aims to investigate the effects of vanillic acid (VA) on memory impairment, locomotion and exploratory deficits, as well as histological and hippocampal long-term potentiation (LTP) injuries induced by tBCCAO procedure followed by reperfusion (BCCAO/R) in rats. Adult male Wistar rats (250-300g) were divided randomly into four groups: Sham-Operated group “Sham”; Vehicle+BCCAO/R group “BCCAO/R”; Vehicle+ Vanillic acid group “VA”; VA (100mg/kg) +BCCAO/R group “VA +BCCAO/R”. Cerebral hypoperfusion was induced after 14days of pretreatment with VA and/or normal saline. To induce the animal model of hypoperfusion, bilateral common carotid arteries were occluded for 30min, followed by 72h of reperfusion. Subsequently, behavioral, histopathological and electrophysiological parameters were evaluated after BCCAO/R. Data showed that pretreatment of VA markedly improved locomotion in tBCCAO rats compared with the untreated BCCAO/R rats (p<0.05). Moreover, pretreatment of VA significantly ameliorated memory impairment in “VA+BCCAO/R” group compared with the “BCCAO/R” group (P<0.01). The field excitatory postsynaptic potential (fEPSP) amplitude and slope were significantly decreased in “BCCAO/R” group compared with Sham group (P<0.001). Data indicate that fEPSP amplitude and slope were increased in “VA+BCCAO/R” group compared with the “BCCAO/R” group (P<0.001). Furthermore, histopathological observation in VA pretreated tBCCAO rats showing markedly attenuated of cell death (P<0.01) and arrangement of CA1 neurons as compared with the untreated BCCAO/R rats. Our data confirm the protective role of VA against transient cerebral ischemia and reperfusion in rats. Moreover, it proposes that VA has a beneficial role in cerebrovascular insufficiency states.
Electrophysiology; Hypoperfusion; Transient cerebral ischemia; Vanillic acid.
Vanillic Acid Attenuates Effects of Transient Bilateral Common Carotid Occlusion and Reperfusion in Rats
Seyed Esmaeil Khoshnam 1 , Alireza Sarkaki 1 , Layasadat Khorsandi 2 , William Winlow 3 , Mohammad Badavi 1 , Hadi Fathi Moghaddam 4 , Yaghoob Farbood 5