We Offer Worldwide Shipping
Login Wishlist



  • Brand : BIOFRON

  • Catalogue Number : BF-V3005

  • Specification : 99%

  • CAS number : 2182-14-1

  • Formula : C25H32N2O6

  • Molecular Weight : 456.53

  • PUBCHEM ID : 260535

  • Volume : 25mg

In stock

Checkout Bulk Order?

Catalogue Number


Analysis Method






Molecular Weight



White crystalline powder

Botanical Source

Catharanthus roseus

Structure Type



Standards;Natural Pytochemical;API




Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2β,4β,5α,12β,19α)-/methyl (2β,3β,4β,5α,12β,19α)-4-(acetyloxy)-3-hydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate/Vindoline/4-acetoxy-3-hydroxy-16-methoxy-1-methyl-6,7-didehydro-aspidospermidine-3-carboxylic acid methyl ester/(2b,3b,4b,5a,12b,19a)-4-(Acetyloxy)-6,7-didehydro-3-hydroxy-16-methoxy-1-methylaspidospermidine-3-carboxylic Acid Methyl Ester/Methyl (2β,4β,5α,12β,19α)-4-acetoxy-3-hydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate/Vindoline (8CI)/vindolin/Vindoline, (-)-


methyl (1R,9R,10S,11R,12R,19R)-11-acetyloxy-12-ethyl-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[,9.02,7.016,19]nonadeca-2(7),3,5,13-tetraene-10-carboxylate


1.3±0.1 g/cm3



Flash Point

298.4±30.1 °C

Boiling Point

569.8±50.0 °C at 760 mmHg

Melting Point



InChl Key

WGK Germany


HS Code Reference


Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:2182-14-1) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Article Available.

Description :

Relaxant effect of vindoline in isolated rat renal arteries PUMID/DOI:无 Chinese Pharmacological Bulletin, 2012, 28(8):1096 -100. To explore the underlying relaxation mechanisms of Vindoline in isolated rat renal arteries.Methods Rings were quickly isolated and suspended in a Multi Myograph System and changes of isometric tension were recorded in the absence or presence of different receptor inhibitors or ion channel blockers.Results Vindoline produced a dose-dependent relaxation in rings with or without endothelia contracted by phenylephrine or KCl.Treatment with TEA+ or Ro-34-0432 slightly blunt the relaxation induced by Vindoline,whereas gliclamide,BaCl2 or Y-27632 failed to affect this relaxant effect.Vindoline reduced the contraction evoked by CaCl2 in Ca-free 60 mmol·L-1 K+ Kreb′s solution,as well as in(-)-Bay K8644 in 15 mmol·L-1 K+ solution.In addition,Vindoline caused the parallel relaxation in rings with or without endothelia.Conclusions The current results suggest that Vindoline dilates renal arteries in vitro through one or more pathways including inhibition of calcium entry,TEA+-sensitive potassium channel or protein kinase pathways in vascular smooth muscle cells. Vincamine and Vindoline from Catharanthus roseus linn. Protects the Gastric Mucosa of Gastric Ulcer in Rats PUMID/DOI:DOI: 10.5567/pharmacologia.2013.243.248 Pharmacologia, 2013, 4(2013):243-8. Currently, natural products have been shown to present interesting biological and pharmacological activities and are used as chemotherapeutic agents. Plants have historically been used in treating cancer and are recognized for their ability to produce secondary metabolites. Objective: The current study was designed to evaluate the antiulcer activity of total extract as well as several fractions from Cantharanthus roseous Linn. (Family; Apocyanaceae) leaves. The bioassay guided chloroform fraction of the ethanol extract yielded two major compounds which have shown a promising antiulcer activity. Materials and methods: C. roseus leaves were evaluated against Cold Restraint Ulcer (CRU), Aspirin (AS), Alcohol (AL) and Pyloric ligation (PL) induced gastric ulcer models in rats. Potential anti-ulcer activity was observed. Results: Potential anti-ulcer activity was observed against CRU (75.18%), AS (50.00%), AL (65.00%) and PL (50.00%) induced ulcer models. The standard drug omeprazole (10 mg kg-1, p.o.) showed 77.34% protection against CRU, 57.08% against AS and 69.42% against PL induced ulcer model. Sucralfate, another standard drug (500 mg kg-1, p.o.) showed 62.72% protection in AL induced ulcer model. Ethanol extract of C. roseus leaves significantly reduced free acidity (17.78%), total acidity (8.05%) and up regulated mucin secretion by 25.11%, respectively. Phytochemical investigations of chloroform fraction yielded vincamine and Vindoline . Further, Fr-CHCl3 and its compounds vincamine and Vindoline significantly showing protection against CRU 81.08 and 81.20%, respectively, confirming their anti-ulcer activity. Discussion and conclusion: The anti-ulcerogenic activity of the chloroform fraction might be due to its anti-secretory activity. This study is the first of its kind to show significant anti-ulcer effect of C. roseus. Therefore, it could act as a potent therapeutic agent against peptic ulcer disease. Natural product vindoline stimulates insulin secretion and efficiently ameliorates glucose homeostasis in diabetic murine models PUMID/DOI:24012527 J Ethnopharmacol. 2013 Oct 28;150(1):285-97. To systematically investigate the potential anti-diabetic effects and the underlying anti-diabetic mechanisms of Vindoline, one of the alkaloids in Catharanthus roseus.||MATERIALS AND METHODS:||The regulation of Vindoline against the glucose-stimulated insulin secretion (GSIS) was examined in insulinoma MIN6 cells and primary pancreatic islets. Insulin concentration was detected by Elisa assay. Diabetic models of db/db mice and type 2 diabetic rats induced by high-fat diet combining with streptozotocin (STZ/HFD-induced type 2 diabetic rats) were used to evaluate the anti-diabetic effect of Vindoline in vivo. Daily oral treatment with Vindoline (20mg/kg) to diabetic mice/rats for 4 weeks, body weight and blood glucose were determined every week, oral glucose tolerance test (OGTT) was performed after 4 weeks.||RESULTS:||Vindoline enhanced GSIS in both glucose- and dose-dependent manners (EC50 = 50 μM). It was determined that Vindoline acted as a Kv2.1 inhibitor able to reduce the voltage-dependent outward potassium currents finally enhancing insulin secretion. It protected β-cells from the cytokines-induced apoptosis following its inhibitory role in Kv2.1. Moreover, Vindoline (20mg/kg) treatment significantly improved glucose homeostasis in db/db mice and STZ/HFD-induced type 2 diabetic rats, as reflected by its functions in increasing plasma insulin concentration, protecting the pancreatic β-cells from damage, decreasing fasting blood glucose and glycated hemoglobin (HbA1c), improving OGTT and reducing plasma triglyceride (TG).||CONCLUSION:||Our findings suggested that Vindoline might contribute to the anti-diabetic effects of Catharanthus roseus, and this natural product may find its more applications in the improvement of β-cell dysfunction and further the potential treatment of type 2 diabetes.