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Vitamin B12

$43

  • Brand : BIOFRON

  • Catalogue Number : BF-V2007

  • Specification : 98%

  • CAS number : 68-19-9

  • Formula : C63H88CoN14O14P

  • Molecular Weight : 1355.38

  • PUBCHEM ID : 5311498

  • Volume : 20mg

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Quantity
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Catalogue Number

BF-V2007

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

-20℃

Molecular Weight

1355.38

Appearance

Colorless crystal

Botanical Source

synthesis

Structure Type

Alkaloids

Category

Standards;Natural Pytochemical;API

SMILES

CC1=CC2=C(C=C1C)N(C=N2)C3C(C(C(O3)CO)OP(=O)([O-])OC(C)CNC(=O)CCC4(C(C5C6(C(C(C(=C(C7=NC(=CC8=NC(=C(C4=N5)C)C(C8(C)C)CCC(=O)N)C(C7(C)CC(=O)N)CCC(=O)N)C)[N-]6)CCC(=O)N)(C)CC(=O)N)C)CC(=O)N)C)O.[C-]#N.[Co+3]

Synonyms

cob(II)alamin/vitral/Vb12/cotel/vibalt/embiol/Vitamin b12/Cyanocobalamin/CN-13-epiCbl/covit/cn-b12/vitamin B-12/cyomin/Bedoz/CN-CBL

IUPAC Name

cobalt(3+);[(2R,3S,4R,5S)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2R)-1-[3-[(1R,2R,3R,5Z,7S,10Z,12S,13S,15Z,17S,18S,19R)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7,12,17-tetrahydro-1H-corrin-24-id-3-yl]propanoylamino]propan-2-yl] phosphate;cyanide

Density

Solubility

Flash Point

48.2 °F

Boiling Point

Melting Point

>300ºC

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

2936260000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:68-19-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

32002975

Abstract

Abtract Objective: The auditory brainstem response (ABR) has been reported as normal in patients with vitamin B12 deficiency, but there have also been reported cases of interference in amplitude responses. However, studies investigating the effects of vitamin B12 on auditory response are limited in patients with tinnitus. The aim of this study was to investigate the ABR findings in patients with tinnitus together with vitamin B12 deficiency.

MATERIAL AND METHODS:
Twenty-eight patients with tinnitus-related vitamin B12 deficiency were included in the study. Their serum vitamin B12 levels were lower than 200 pg/ml. Patients were between 19 and 58 years with a mean age of 36.82 ± 11.19 (ratio: male/female, 6/22). ABR was performed in all patients. Latencies ( I, II, III, IV, V), interpeak latencies (I-III, III-V, I-V) and amplitudes were evaluated. Neurologic and ear physical examinations were evaluated and brain magnetic resonance imaging (MRI) was also performed in all patients.

RESULTS:
Neurologic,ear-auditory physical examinations and brain MRI findings were normal in all patients. Wave latencies and interpeak latencies were normal in all patients. Six patients (21.42 %) had low amplitude in their ABR. In one of them, the left-sided response showed a mild amplitude decrease in all waves compared to the right-side. Bilateral mild low amplitude was observed in 4 (66.6 %) patients in ABR findings.

CONCLUSION:
These results support that ABR findings can be influenced in vitamin B12 deficiency patients having tinnitus. More detailed studies are needed in tinnitus associated with vitamin B12 deficient patients. Key words: Auditory brainstem response, Tinnitus, Vitamin B12 deficiency, Neurophysiology, Low amplitude.

Title

Auditory Brainstem Response in Patients with Tinnitus Associated with Vitamin B12 Deficiency.

Author

Kisli M1, Sacmacı H1.

Publish date

2019 Sep 15

PMID

31990304

Title

Treatment of Iron Deficiency After Gastric Bypass.

Publish date

2020 Jan 28

PMID

31957765

Abstract

Highly water-soluble cyanocobalamin (also known as vitamin B12) is the most structurally macrocyclic complex comprising cobalt in the center of a corrin ring. Interestingly, it acts as a robust electrocatalyst in water oxidation at ∼0.58 V overpotential with a faradaic efficiency of 97.50% under neutral buffered conditions. The catalyst is impressively stable even after long-term bulk electrolysis, and homogeneous in nature, as established by a series of experiments and characterization techniques.

Title

Macrocyclic cyanocobalamin (vitamin B12) as a homogeneous electrocatalyst for water oxidation under neutral conditions.

Author

Shahadat HM 1, Younus HA , Ahmad N , Zhang S , Zhuiykov S , Verpoort F .

Publish date

2020 Feb 13


Description :

Vitamin B12 is a water soluble vitamin with a key role in the normal functioning of the brain and nervous system, and for the formation of blood.Target: OthersVitamin B12 is a water-soluble vitamin with a key role in the normal functioning of the brain and nervous system, and for the formation of blood. It is one of the eight B vitamins. It is normally involved in the metabolism of every cell of the human body, especially affecting DNA synthesis and regulation, but also fatty acid synthesis (especially odd chain fatty acids) and energy production. Vitamin B12 normally plays a significant role in the metabolism of every cell of the body, especially affecting the DNA synthesis and regulation but also fatty acid synthesis and energy production. However, many (though not all) of the effects of functions of B12 can be replaced by sufficient quantities of folic acid (vitamin B9), since B12 is used to regenerate folate in the body. Most vitamin B12 deficiency symptoms are actually folate deficiency symptoms, since they include all the effects of pernicious anemia and megaloblastosis, which are due to poor synthesis of DNA when the body does not have a proper supply of folic acid for the production of thymine due to methyl trapping. When sufficient folic acid is available, all known B12 related deficiency syndromes normalize, save those narrowly connected with the vitamin B12-dependent enzymes Methylmalonyl Coenzyme A mutase, and 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR), also known as methionine synthase; and the buildup of their respective substrates (methylmalonic acid, MMA) and homocysteine.Coenzyme B12's reactive C-Co bond participates in three main types of enzyme-catalyzed reactions [1, 2].