(5R)-5-[(1S)-1,2-Dihydroxyethyl]-3,4-dihydroxyfuran-2(5H)-one/L-Ascorbic acid/L-Ascorbic acid（C)/(5R)-5-[(1S)-1,2-Dihydroxyethyl]-3,4-dihydroxy-2(5H)-furanone/Calscorbate/monodehydro-L-ascorbic acid/Cetebe/4-18-00-03038/(5R)-5-[(1S)-1,2-Dihydroxyethyl]-3,4-dihydroxy-2(5H)-furanone/L-Threoascorbic acid,Antiscorbutic factor,Vitamin C/L(+)-Ascorbic acid/(R)-5-((S)-1,2-Dihydroxyethyl)-3,4-dihydroxyfuran-2(5H)-one/(5R)-5-[(1S)-1,2-Dihydroxyethyl]-3,4-dihydroxy-2(5H)-furanon/Vitamin C
Methanol; Water; DMSO
552.7±50.0 °C at 760 mmHg
190-194 °C (dec.)
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Personal Projective Equipment
For Reference Standard and R&D, Not for Human Use Directly.
provides coniferyl ferulate(CAS#:50-81-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
In humans, ascorbic acid, better known as vitamin C, is a true vitamin because humans lack the ability to synthesise it. Vitamin C exhibits a number of enzymatic and non-enzymatic effects but all are accounted for by the ability of vitamin C to donate electrons and therefore acts as a reducing agent. It has a wide range of functions. For example, it acts as co-factor for a number of enzymes including those involved in collagen hydroxylation, prevents oxidative damage to DNA and intracellular proteins, and in plasma it increases endothelium-dependent vasodilatation, and reduces extracellular oxidants from neutrophils. Deficiency in vitamin C results in the potentially fatal disease scurvy, which can be cured only by administering vitamin C. It has been shown that in individuals with gingivitis and periodontitis, plasma vitamin C levels are lower than in healthy controls. In periodontitis, a reduced capacity to absorb vitamin C may play a role. The manner in which vitamin C data are obtained from blood significantly impacts the final value obtained and therefore data validity. Plasma vitamin C levels of 56.8 μmol/l may be regarded as the optimum plasma level. In order to achieve this level, at least 200 mg vitamin C per day should be ingested. It is advisable to obtain vitamin C through the consumption of fruit and vegetables rather than supplements.
ascorbic acid; gingivitis; periodontitis; scurvy; vitamin C
Vitamin C and Its Role in Periodontal Diseases - The Past and the Present: A Narrative Review.
Van der Velden U.
Vitamin C levels are decreased in arthritis patients and reduced levels following surgery may impair adequate healing.
This study measured changes in vitamin C and inflammatory markers in patients undergoing total knee arthroplasty (TKA).
Venous blood samples were collected from 10 patients during the preoperative to postoperative period. Vitamin C, interleukin-1β, interleukin-6 (IL-6), and C-reactive protein (CRP) levels were measured using various assays.
No significant changes in vitamin C levels were measured. However, all participants had suboptimal preoperative vitamin C levels and 90% had suboptimal levels postoperatively. IL-6 and CRP levels significantly increased during the immediate postoerative period.
There was a rise in inflammation following TKA while vitamin C levels did not significantly change during this short study period. Of note, every patient had suboptimal vitamin C levels prior to surgery and 90% continued with suboptimal levels two days postoperatively.
Vitamin C; inflammatory cytokines; total knee arthroplasty
Vitamin C and inflammatory cytokine levels in elective total knee arthroplasty.
Shah S1, Brown C1, Owen J2, Fisher B3, Natarajan R3, Kates S4.
2020 Mar 30
Ascorbic acid (vitamin C) is critical for Schwann cells to myelinate peripheral nerve axons during development and remyelination after injury. However, its exact mechanism remains elusive. Vitamin C is a dietary nutrient that was recently discovered to promote active DNA demethylation. Schwann cell myelination is characterized by global DNA demethylation in vivo and may therefore be regulated by vitamin C. We found that vitamin C induces a massive transcriptomic shift (n = 3,848 genes) in primary cultured Schwann cells while simultaneously producing a global increase in genomic 5-hydroxymethylcytosine (5hmC), a DNA demethylation intermediate which regulates transcription. Vitamin C upregulates 10 pro-myelinating genes which exhibit elevated 5hmC content in both the promoter and gene body regions of these loci following treatment. Using a mouse model of human vitamin C metabolism, we found that maternal dietary vitamin C deficiency causes peripheral nerve hypomyelination throughout early development in resulting offspring. Additionally, dietary vitamin C intake regulates the expression of myelin-related proteins such as periaxin (PRX) and myelin basic protein (MBP) during development and remyelination after injury in mice. Taken together, these results suggest that vitamin C cooperatively promotes myelination through 1) increased DNA demethylation and transcription of pro-myelinating genes, and 2) its known role in stabilizing collagen helices to form the basal lamina that is necessary for myelination.
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5-hydroxymethylcytosine; DNA demethylation; Schwann cell; Vitamin C; myelin
Vitamin C regulates Schwann cell myelination by promoting DNA demethylation of pro-myelinating genes.
Huff TC1, Sant DW1, Camarena V1, Van Booven D1, Andrade NS2, Mustafi S1, Monje PV3, Wang G1,4.
2020 Mar 26
L-Ascorbic acid is an effective reducing agent and donor antioxidant.