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Vitamin D3

$52

  • Brand : BIOFRON

  • Catalogue Number : BD-P0673

  • Specification : 98.0%(HPLC)

  • CAS number : 67-97-0

  • Formula : C27H44O

  • Molecular Weight : 384.64

  • PUBCHEM ID : 5283711

  • Volume : 25mg

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Catalogue Number

BD-P0673

Analysis Method

Specification

98.0%(HPLC)

Storage

-20℃

Molecular Weight

384.64

Appearance

White powder

Botanical Source

Structure Type

Category

SMILES

CC(C)CCCC(C)C1CCC2C1(CCCC2=CC=C3CC(CCC3=C)O)C

Synonyms

Oxarol/Vitamin D3/Ebivit/Cholecalciferolum/(3S,5Z,7E)-9,10-Secocholesta-5,7,10-trien-3-ol/(1S,3Z)-3-[(2E)-2-{(1R,3aS,7aR)-1-[(1R)-1,5-Dimethylhexyl]-7a-methyloctahydro-4H-inden-4-yliden}ethyliden]-4-methylidencyclohexanol/Cyclohexanol, 3-[(2E)-2-[(1R,3aS,7aR)-1-[(1R)-1,5-dimethylhexyl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-, (1S,3Z)-/Micro-Dee/(5Z,7E)-(3S)-9,10-secocholesta-5,7,10(19)-trien-3-ol//DeparalFeraCo/9,10-secocholesta-5,7,10-trien-3-ol, (3S,5Z,7E)-/Prezios/cholecalciferol/(1S,3Z)-3-[(2E)-2-[(1R,3aS,7aR)-1-[(1R)-1,5-dimethylhexyl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylenecyclohexanol/Vi-De3/MC 1275/Granuvit D3/Devaron/(3b,5Z,7E)-9,10-Secocholesta-5,7,10(19)-trien-3-olcyclohexanol, 3-[(2E)-2-[(1R,3aS,7aR)-1-(1,5-dimethylhexyl)octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-, (1S,3Z)-/rampage/vitamin D3 powder/D3-Vicotrat/NEO Dohyfral D3/(1S,3Z)-3-[(2E)-2-{(1R,3aS,7aR)-1-[(1R)-1,5-dimethylhexyl]-7a-methyloctahydro-4H-inden-4-ylidene}ethylidene]-4-methylidenecyclohexanol/Vigantol/9,10-Secocholesta-5,7,10(19)-trien-3-ol, (3β,5Z,7E)-/(1S,3Z)-4-Methylene-3-[(2E)-2-{(1R,3aS,7aR)-7a-methyl-1-[(2R)-6-methyl-2-heptanyl]octahydro-4H-inden-4-ylidene}ethylidene]cyclohexanol/colecalciferol/Videkhol/(3β,Z,7E)-9,10-Secocholesta-5,7,10(19)-trien-3-ol/[3H]-Vitamin D3/9,10-Secocholesta-5,7,10(19)-trien-3b-ol/calciol/Provitina/VITAMIN D

IUPAC Name

Applications

Density

1.0±0.1 g/cm3

Solubility

Methanol; Chloroform; Ethyl Acetate

Flash Point

214.2±15.1 °C

Boiling Point

496.4±24.0 °C at 760 mmHg

Melting Point

83-86 °C(lit.)

InChl

InChl Key

QYSXJUFSXHHAJI-FVUVGDFOSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:67-97-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

32014913

Abstract

AIM:
A commercially available light emitting diode (LED) that transmitted narrow band ultraviolet B (UVB) radiation was evaluated for its efficacy and efficiency to produce vitamin D3 in human skin.

MATERIALS AND METHODS:
Human skin samples were obtained from surgical procedures. The LED had peak emission wavelength of 295 nm. Skin samples were exposed to the UVB-LED for varying times and then were analyzed by high-pressure liquid chromatography (HPLC) to determine the vitamin D3 content.

RESULTS:
There was a statistically significant time- and dose-dependent increase in the percent of 7-dehydrocholesterol that was converted to vitamin D3 in the skin type II samples; 1.3%±0.5, 2.3%±0.6 and 4.5%±1.67 after exposure to 0.75 (11.7 mJ/cm2), 1.5 (23.4 mJ/cm2) and 3 (46.8 mJ/cm2) minimal erythemal doses (MEDs), respectively.

CONCLUSION:
The UVB-LED was effective and efficient in generating vitamin D3 in human skin, in vitro. The amount of vitamin D3 production increased in a dose-dependent fashion with increased UVB energy. UVB-LEDs can be developed for devices that can efficiently produce vitamin D3 in human skin.

Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

KEYWORDS

Previtamin D3; human skin; ultraviolet B radiation; ultraviolet radiation light emitting diode (LED); vitamin D3

Title

Evaluation of a Ultraviolet B Light Emitting Diode (LED) for Producing Vitamin D3 in Human Skin.

Author

Veronikis AJ1, Cevik MB1, Allen RH1, Shirvani A1, Sun A1, Persons KS1, Holick MF2.

Publish date

2020 Feb

PMID

31906679

Abstract

Vitamin D3 cholecalciferol is produced from its cholesterol precursors in the skin under the influence of ultraviolet calc. Its subsequent hydroxylation in the liver and kidneys leads to the formation of its most active metabolite calcitriol, which plays one of the key roles in the management of calcium phosphate metabolism. However, it also has the ability to regulate the function of a number of cells and tissues that express the vitamin D receptor. The most widespread method to evaluate the status of vitamin D in the body is to measure serum levels of its meta-bolite 25 hydroxyvitamin D – 25 (OH) D. Optimal values range between 75-125 nmoll / l. Its deficit is widespread in the human population worldwide and has a significant impact on the prevalence of metabolic bone diseases. Its deficiency may support the dysfunction of many other body systems. Ensuring optimal levels of vitamin D in the popula-tion is a challenge not only for health care and especially for government administration.

KEYWORDS

bone diseases; calciferol; calcium metabolism; deficiency; pleiotropic effect

Title

Vitamin D deficiency and its health effects.

Author

Horak P.

PMID

31892613

Abstract

BACKGROUND/AIM:
To assess the effectiveness of three UV emitting lamps on the cutaneous production of vitamin D3, a marker of DNA damage and nitric oxide production in human skin.

MATERIALS AND METHODS:
Human skin samples (skin types II, III and IV) obtained from surgery were exposed to three different UV emitting lamps for varying times and then extracted and chromatographed to determine the vitamin D3 content. The skin samples exposed to the 3 UV emitting lamps were also evaluated for 8-hydroxy-2′-deoxyguanosine (a marker of DNA damage) and nitric oxide production.

RESULTS:
It was observed that the spectral output of the 3 lamps had different effects on the cutaneous production of vitamin D3, 8-hydroxy-2′-deoxyguanosine and nitric oxide production. One lamp demonstrated optimal production of vitamin D3 with the least amount of DNA damage and intermediate production of nitric oxide suggesting that it could be developed into a device for treating vitamin D deficiency.

CONCLUSION:
The spectral output of the experimental UVB emitting lamps significantly influenced the cutaneous production of vitamin D3 8-hydroxy-2′-deoxyguanosine and nitric oxide.

Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

KEYWORDS

8-hydroxy-2’-deoxyguanosine; DNA damage; Previtamin D3; human skin; nitric oxide; nitrite; vitamin D

Title

Evaluation of Effectiveness of Ultraviolet Emitting Lamps on the Cutaneous Production of Vitamin D3: Relationship of the Lamps Vitamin D3 Producing Potential to the Production of 8-Hydroxy-2'-Deoxyguanosine and Nitric Oxide.

Author

Shirvani A1, Persons KS1, Holick MF2.

Publish date

2020 Jan