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provides coniferyl ferulate(CAS#:56973-41-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
Aims: Previous studies in our laboratory have demonstrated the increased neuronal apoptosis in the hippocampus and abnormal hippocampal morphology after severe stress, which directly correlates to the pathogenesis of post-traumatic stress disorder (PTSD). This study aims to investigate the effects of Lycium barbarum polysaccharide (LBP) on intrusive memory of posttraumatic stress in rats, and to analyze the mechanism of regeneration/apoptosis balance in the hippocampal neurons.
Main methods: The experimental rats received 20 inescapable electric foot shocks in an enclosed box for six times in three days. The rats were treated by intragastric administration of LBP (20mg/kg/day) for 3 days before stress in the stress plus prophylactic group, and for 28 days after stress in the stress plus therapeutic group. The emotion, intrusive memory-related behavior (freezing, open field, pain latency, spatial cognition), hippocampus cell morphology, and relation of neurogenesis and apoptosis in dental gyrus of the hippocampus were observed. The hippocampus volume was evaluated by stereology. Meanwhile, the neurogenesis and apoptosis were analyzed with 5-bromo-2′-deoxyuridine and terminal deoxylnucleotidyl transferase mediated-dUTP nick end labeling (TUNEL) method.
Key findings: The treatment of LBP in pre-stress and post-stress had obvious beneficial effect on the behaviors and neurogenesis. The stressed rats showed improvement of intrusive memory related cognition defect, alleviation of the apoptosis in the hippocampus and recovery for the neurogenesis, which was related to the hippocampus volume after LBP treatment.
Significance: LBP treatment might effectively improve the traumatic cognition defect induced by severe stress and be useful for the intrusive memory-related cognition recovery.
(5alpha, 6alpha, 7alpha, 22R)-5-hydroxy-6, 7: 22, 26-diepoxyergosta-2, 24-diene-1, 26-dione (PubChem CID: 14236711); 56973-41-2 (PubChem CID: 14236711); Apoptosis; Hippocampus; Hypothalamus-pituitary-adrenal (HPA) axis; Intrusive memory; Lycium barbarum polysaccharide (LBP); Lycium substance B (PubChem CID: 14236711); Neurogenesis; Posttraumatic stress; UNII-9YU877VU8K (PubChem CID: 14236711); Withanolide B (PubChem CID: 14236711).
Lycium barbarum polysaccharide improves traumatic cognition via reversing imbalance of apoptosis/regeneration in hippocampal neurons after stress
Jie Gao 1, Can Chen 1, Yuan Liu 1, Yingyu Li 1, Zaiyun Long 1, He Wang 1, Yundong Zhang 2, Jianfeng Sui 3, Yamin Wu 1, Liangming Liu 1, Ce Yang 4
2015 Jan 15
Withania somnifera (Ashwagandha) is an efficient medicinal plant known in Ayurveda and Chinese medicine since ancient times, whose extracts are consumed orally as food supplement or as a health tonic owing to its several restorative properties for various CNS disorders, inflammation, tumour, stress, rheumatism etc. In this study, we have analyzed the binding interaction of four derivatives of Withania somnifera (Withanolide A, Withanolide B, Withanoside IV and Withanoside V) with HSA because of their important pharmacological properties. To unravel the binding between derivatives of Withania somnifera and HSA, fluorescence spectroscopy was used. Binding studies were further studied by molecular docking and dynamics and results confirmed greater stability upon binding of derivatives with HSA. Circular dichroism data illustrated change in the secondary structure of protein upon interaction with these derivatives, particularly the helical structure was increased and β-sheets and random coils were decreased. Furthermore, morphological and topological changes were observed using AFM and TEM upon binding of ligands with HSA indicating that HSA-withnoside/withanolide complexes were formed. All the results cumulatively demonstrate strong binding of withanosides and withanolides derivatives with serum albumin, which should further be explored to study the pharmacokinetics and pharmacodynamics of these derivatives.
Elucidating the active interaction mechanism of phytochemicals withanolide and withanoside derivatives with human serum albumin
Shreya Dubey, Data curation, Formal analysis, Investigation, Methodology, Validation, Writing - original draft, Monika Kallubai, Data curation, Investigation, Methodology, Software, Validation, Visualization, Arijit Sarkar, Data curation, Methodology, Validation, and Rajagopal Subramanyam, Conceptualization, Funding acquisition, Investigation, Project administration, Resources, Writing - original draft, Writing - review & editing*