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Xanthoxylin

$64

  • Brand : BIOFRON

  • Catalogue Number : BD-P0669

  • Specification : 98.0%(GC)

  • CAS number : 90-24-4

  • Formula : C10H12O4

  • Molecular Weight : 196.2

  • Volume : 25mg

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Catalogue Number

BD-P0669

Analysis Method

HPLC,NMR,MS

Specification

98.0%(GC)

Storage

2-8°C

Molecular Weight

196.2

Appearance

Powder

Botanical Source

Structure Type

Simple Phenolic Compounds

Category

SMILES

CC(=O)C1=C(C=C(C=C1OC)OC)O

Synonyms

IUPAC Name

Applications

Density

1.2±0.1 g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

141.2±20.0 °C

Boiling Point

355.1±37.0 °C at 760 mmHg

Melting Point

80-84 °C(lit.)

InChl

InChI=1S/C10H12O4/c1-6(11)10-8(12)4-7(13-2)5-9(10)14-3/h4-5,12H,1-3H3

InChl Key

FBUBVLUPUDBFME-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

2914500000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:90-24-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

29362398

Abstract

Ruthenium-based compounds have gained great interest due to their potent cytotoxicity in cancer cells; however, much of their potential applications remain unexplored. In this paper, we report the synthesis of a novel ruthenium complex with xanthoxylin (RCX) and the investigation of its cellular and molecular action in human hepatocellular carcinoma HepG2 cells. We found that RCX exhibited a potent cytotoxic effect in a panel of cancer cell lines in monolayer cultures and in a 3D model of multicellular cancer spheroids formed from HepG2 cells. This compound is detected at a high concentration in the cell nuclei, induces DNA intercalation and inhibits DNA synthesis, arresting the cell cycle in the S-phase, which is followed by the activation of the caspase-mediated apoptosis pathway in HepG2 cells. Gene expression analysis revealed changes in the expression of genes related to cell cycle control, apoptosis and the MAPK pathway. In addition, RCX induced the phosphorylation of ERK1/2, and pretreatment with U-0126, an MEK inhibitor known to inhibit the activation of ERK1/2, prevented RCX-induced apoptosis. In contrast, pretreatment with a p53 inhibitor (cyclic pifithrin-α) did not prevent RCX-induced apoptosis, indicating the activation of a p53-independent apoptosis pathway. RCX also presented a potent in vivo antitumor effect in C.B-17 SCID mice engrafted with HepG2 cells. Altogether, these results indicate that RCX is a novel anticancer drug candidate.

Title

A novel ruthenium complex with xanthoxylin induces S-phase arrest and causes ERK1/2-mediated apoptosis in HepG2 cells through a p53-independent pathway

Author

Nanashara C de Carvalho 1, Sara P Neves 1, Rosane B Dias 1, Ludmila de F Valverde 1, Caroline B S Sales 2, Clarissa A G Rocha 1, Milena B P Soares 1 3, Edjane R Dos Santos 4, Regina M M Oliveira 4, Rose M Carlos 4, Paulo C L Nogueira 5, Daniel P Bezerra 6

Publish date

2018 Jan 23;

PMID

26232573

Abstract

The ternary terbium(III) complexes [Tb(HDAP)3⋅biq], [Tb(HDAP)3⋅dmph] and [Tb(HDAP)3⋅bathophen] were prepared by using methoxy substituted hydroxyketone ligand HDAP (2-hydroxy-4,6-dimethoxyacetophenone) and an ancillary ligand 2,2-biquinoline or 5,6-dimethyl-1,10-phenanthroline or bathophenanthroline respectively. The ligand and synthesized complexes were characterised based on elemental analysis, FT-IR and (1)H NMR. Thermal behaviour of the synthesized complexes illustrates the general decomposition patterns of the complexes by thermogravimetric analysis. Photophysical properties such as excitation spectra, emission spectra and luminescence decay curves of the complexes were investigated in detail. The main green emitting peak at 548nm can be attributed to (5)D4→(7)F5 of Tb(3+) ion. Thus, these complexes might be used to make a bright green light-emitting diode for display purpose. In addition the in vitro antibacterial activities of HDAP and its Tb(III) complexes against Bacillus subtilis, Staphylococcus aureus, Escherichia coli and antifungal activities against Candida albicans and Aspergillus niger are reported. The Tb(3+) complexes were found to be more potent antimicrobial agent as compared to the ligand. Among all these complexes, [Tb(HDAP)3⋅bathophen] exhibited excellent antimicrobial activity which proves its potential usefulness as an antimicrobial agent. Furthermore, in vitro antioxidant activity tests were carried out by using DPPH method which indicates that the complexes have considerable antioxidant activity when compared with the standard ascorbic acid.

KEYWORDS

Antimicrobial activity; Antioxidant; Bright green; Luminescence; Tb(3+).

Title

Synthesis, photoluminescence and biological properties of terbium(III) complexes with hydroxyketone and nitrogen containing heterocyclic ligands

Author

Poonam 1, Rajesh Kumar 2, Priti Boora 1, Anurag Khatkar 3, S P Khatkar 1, V B Taxak 4

Publish date

2016 Jan 5;

PMID

25345134

Abstract

Objective: To study the chemical constituents of n-BuOH extract from Phyllanthus matsumurae.

Methods: Column chromatography was used for the isolation and purification. Spectroscopic methods including H-NMR, 13C-NMR and MS were used for the identification of structures.

Results: Six compounds were isolated from the n-BuOH extract of 75% alcohol extract of the whole plant and identified as ellagic acid (1), phyllanthuspermin B (2), phyllanthuspermin C (3), xanthoxylin (4), hesperetin-7-O-[6-O-(alpha-L-rhamnopy ranosyl)] -beta-D-glucopyranoside (5) and 4-O-methylgallic acid (6).

Conclusion: Compounds 2 – 6 are obtained from this plant for the first time.

Title

[Chemical constituents of n-BuOH extract from Phyllanthus matsumurae]

Author

Chun-Ling Zhu

Publish date

2014 Apr;