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Z-Guggulsterone

$519

Brand : BIOFRON
Catalogue Number : BN-O0019
Specification : 98%(HPLC)
CAS number : 39025-23-5
Formula : C21H28O2
Molecular Weight : 312.45
PUBCHEM ID : 6450278
Volume : 5mg

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Catalogue Number

BN-O0019

Analysis Method

Specification

98%(HPLC)

Storage

-20℃

Molecular Weight

312.45

Appearance

Powder

Botanical Source

Structure Type

Category

SMILES

CC=C1C(=O)CC2C1(CCC3C2CCC4=CC(=O)CCC34C)C

Synonyms

(8R,9S,10R,13S,14S,17Z)-17-ethylidene-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15-decahydrocyclopenta[a]phenanthrene-3,16-dione

IUPAC Name

Density

1.1±0.1 g/cm3

Solubility

Soluble to 20 mM in DMSO with gentle warming and to 10 mM in ethanol with gentle warming

Flash Point

172.3±25.7 °C

Boiling Point

463.3±45.0 °C at 760 mmHg

Melting Point

188-190°

InChl

InChl Key

WDXRGPWQVHZTQJ-OSJVMJFVSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:39025-23-5) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

32196098

Abstract

Purpose: Inflammation, hyaluronan production, and adipogenesis are the main pathological events leading to Graves’ orbitopathy (GO). Guggulsterone (GS), a phytosterol found in the resin of the guggul plant, is a well-known treatment for several inflammatory disorders, such as arthritis, obesity, and hyperlipidemia. Here we investigated the effects of GS treatment on GO pathology.

Methods: Using primary cultures of orbital fibroblasts from GO patients and non-GO controls, we examined the effects of GS on hyaluronan production and the production of proinflammatory cytokines induced by interleukin (IL)-1β, using real-time reverse transcription-polymerase chain reaction analysis, western blots, and enzyme-linked immunosorbent assays. Further, adipogenic differentiation was evaluated by quantification of Oil Red O staining and assessment of protein levels of peroxisome proliferator activator gamma (PPARγ), CCAAT-enhancer-binding proteins (C/EBP) α and β, and sterol regulatory element-binding protein-1 (SREBP-1).

Results: Treatment with noncytotoxic concentrations of GS resulted in the dose-dependent inhibition of IL-1β-induced inflammatory cytokines, including IL-6, IL-8, MCP-1, and COX-2, at both mRNA and protein levels. The hyaluronan level was also significantly suppressed by GS. Moreover, GS significantly decreased the formation of lipid droplets and expression of PPARγ, C/EBP α/β, and SREBP-1 in a dose-dependent manner. GS pretreatment attenuated the phosphorylation of nuclear factor-kappa B induced by IL-1β.

Conclusions: Our data show significant inhibitory effects of GS on inflammation, production of hyaluronan, and adipogenesis in orbital fibroblasts. To our knowledge, this is the first in vitro preclinical evidence of the therapeutic effect of GS in GO

Title

Therapeutic Effect of Guggulsterone in Primary Cultured Orbital Fibroblasts Obtained From Patients with Graves' Orbitopathy

Author

Bo Ram Kim 1, Jinjoo Kim 1, Jong Eun Lee 1, Eun Jig Lee 1, Jin Sook Yoon 1

Publish date

2020 Mar 9;

PMID

31608826

Title

How can microsphere-mediated delivery of small molecules serve as a novel tool for engineering tissues from stem cells?

Author

Stephanie Michelle Willerth 1

Publish date

2019 Nov;

PMID

31590195

Abstract

Commiphora gileadensis, locally known as becham, is a plant used in traditional Arabian medicine for treating headache, constipation, stomach, joint pain, and inflammatory disorders. Several studies have reported its antibacterial properties; however, no study has demonstrated its antiviral activity. This study aimed to evaluate the antiviral activity of C. gileadensis as well as to isolate its active compound and investigate its mode of action. This activity was evaluated using 4 viruses, herpes simplex virus type 2 (HSV-2), respiratory syncytial virus type B (RSV-B), coxsackie virus B type 3, and adenovirus type 5 by performing the plaque reduction assay and the 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays for enveloped and nonenveloped viruses, respectively. The methanol extract of C. gileadensis leaves only showed antiviral activity against enveloped viruses with a selectivity index of 11.19 and 10.25 for HSV-2 and RSV-B, respectively. The study of the mechanism underlying antiviral activity demonstrated a virucidal effect by direct contact with these target viruses. The active compound, isolated using bio-guided assays involving TLC, was identified as guggulsterone by HPLC-diode array detection coupled with electrospray ionization mass spectrometry. Guggulsterone is an antagonist of the bile acid receptor and a modulator of cholesterol metabolism; however, its antimicrobial properties have been reported for the first time in this study.

Georg Thieme Verlag KG Stuttgart · New York.

Title

Virucidal Effect of Guggulsterone Isolated from Commiphora gileadensis

Author

Lamjed Bouslama 1, Bochra Kouidhi 2, Yasir Mohammed Alqurashi 2, Kamel Chaieb 3 4, Adele Papetti 5

Publish date

2019 Nov