Catalogue Number
BN-B1490
Analysis Method
HPLC,NMR,MS
Specification
98%(HPLC)
Storage
-20℃
Molecular Weight
246.3
Appearance
Powder
Botanical Source
This product is isolated and purified from the rhizomes of Curcuma zedoaria
Structure Type
Sesquiterpenoids
Category
Standards;Natural Pytochemical;API
SMILES
CC1=CCCC2(C(O2)C(=O)C3=C(C1)OC=C3C)C
Synonyms
Oxireno[4,5]cyclodeca[1,2-b]furan-10(2H)-one, 1a,3,6,10a-tetrahydro-1a,5,9-trimethyl-/1a,5,9-Trimethyl-1a,3,6,10a-tetrahydrooxireno[4,5]cyclodeca[1,2-b]furan-10(2H)-one
IUPAC Name
(3R,5R,8Z)-5,9,14-trimethyl-4,12-dioxatricyclo[9.3.0.03,5]tetradeca-1(11),8,13-trien-2-one
Density
1.1±0.1 g/cm3
Solubility
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Flash Point
174.7±27.9 °C
Boiling Point
365.3±42.0 °C at 760 mmHg
Melting Point
153.4-153.9℃ (acetone hexane )
InChl
InChI=1S/C15H18O3/c1-9-5-4-6-15(3)14(18-15)13(16)12-10(2)8-17-11(12)7-9/h5,8,14H,4,6-7H2,1-3H3/b9-5-/t14-,15+/m0/s1
InChl Key
CVIVANCKIBYAOP-HBXAWUERSA-N
WGK Germany
RID/ADR
HS Code Reference
2933990000
Personal Projective Equipment
Correct Usage
For Reference Standard and R&D, Not for Human Use Directly.
Meta Tag
provides coniferyl ferulate(CAS#:7727-79-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
No Technical Documents Available For This Product.
24082031
The present study aimed to investigate the hepatotoxicity of zederone isolated from Curcuma elata in mice. Adult male mice were intraperitoneally injected with a single dose of zederone (50-300 mg/kg body weight [BW]). Twenty-four hours after the injection, zederone induced liver enlargement with scattered white foci over the organ. The medium lethal dose (LD₅₀) value at 24 hours of zederone was approximately 223 mg/kg BW. Hepatic centrilobular necrosis with marked increases in plasma alanine transaminase activity and total bilirubin levels was observed. Zederone at a dose of 200 mg/kg BW markedly decreased the activity of superoxide dismutase and the hepatic glutathione content, whereas the activity of catalase was not altered. The compound at this dose also increased the messenger RNA (mRNA) expression of Cyp2b10 and Cyp3a11, which are the main drug-metabolizing enzymes in the liver. The mRNA expression of proinflammatory cytokine tumor necrosis factor α was increased. The nuclear factor-E2-related factor 2 protein, which is the transcription factor regulating the antioxidant gene expression, was decreased. The histopathology of massive hepatic centrilobular necrosis with an increase in the expression of cytochrome P450 (Cyp) suggests that the possible potentiation of zederone-induced hepatotoxicity implicated the induction of Cyps, which leads to the formation of biological reactive metabolites and that cause the oxidative stress and liver cell injuries.
cytochrome P450; liver toxicity; sesquiterpene; zederone
Zederone, a sesquiterpene from Curcuma elata Roxb, is hepatotoxic in mice.
Pimkaew P1, Suksen K, Somkid K, Chokchaisiri R, Jariyawat S, Chuncharunee A, Suksamrarn A, Piyachaturawat P.
2013 Nov-Dec
5706816
Structure of zederone.
Hikino H, Takahashi S, Sakurai Y, Takemoto T, Bhacca NS.
1968 Jun
