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Zingiberensis saponin I

$896

  • Brand : BIOFRON

  • Catalogue Number : BD-P0125

  • Specification : 99.0%(HPLC)

  • CAS number : 91653-50-8

  • Formula : C51H82O22

  • Molecular Weight : 1047.18

  • PUBCHEM ID : 102475150

  • Volume : 25mg

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Catalogue Number

BD-P0125

Analysis Method

HPLC,NMR,MS

Specification

99.0%(HPLC)

Storage

2-8°C

Molecular Weight

1047.18

Appearance

Powder

Botanical Source

Structure Type

Steroids

Category

SMILES

CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CC=C6C5(CCC(C6)OC7C(C(C(C(O7)CO)OC8C(C(C(C(O8)CO)O)OC9C(C(C(C(O9)CO)O)O)O)O)O)OC2C(C(C(C(O2)C)O)O)O)C)C)C)OC1

Synonyms

(2S,3R,4R,5R,6S)-2-[(2R,3R,4S,5S,6R)-5-[(2S,3R,4S,5R,6R)-3,5-dihydroxy-6-(hydroxymethyl)-4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-4-hydroxy-6-(hydroxymethyl)-2-[(1S,2S,4S,5'R,6R,7S,8R,9S,12S,13R,16S)-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,2'-oxane]-16-yl]oxyoxan-3-yl]oxy-6-methyloxane-3,4,5-triol

IUPAC Name

(2S,3R,4R,5R,6S)-2-[(2R,3R,4S,5S,6R)-5-[(2S,3R,4S,5R,6R)-3,5-dihydroxy-6-(hydroxymethyl)-4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-4-hydroxy-6-(hydroxymethyl)-2-[(1S,2S,4S,5'R,6R,7S,8R,9S,12S,13R,16S)-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,2'-oxane]-16-yl]oxyoxan-3-yl]oxy-6-methyloxane-3,4,5-triol

Applications

Study on the water-insoluble steroidal saponins from Dioscorea zingiberensis and cell growth inhibitive effects of steroidal saponins against human hepatocellular carcinoma hep G2 cells PUMID/DOI:Zhao Q B, Huang W, Wen-Fang W U, et al. Study on the water-insoluble steroidal saponins from Dioscorea zingiberensis and cell growth inhibitive effects of steroidal saponins against human hepatocellular carcinoma hepG2 cells[J]. West China Journal of Pharmaceutical Sciences, 2010, 25(5):527-529. Zhao Q B, Huang W, Wen-Fang W U, et al. Study on the water-insoluble steroidal saponins from Dioscorea zingiberensis and cell growth inhibitive effects of steroidal saponins against human hepatocellular carcinoma hepG2 cells[J]. West China Journal of Pharmaceutical Sciences, 2010, 25(5):527-529. OBJECTIVE To study chemical constituents of the water-insoluble extract from Dioscorea zingiberensis C. H. Wright and cell growth inhibitive effects of chemical constituents against HepG2 cells. METHODS The chemical constituents of waterinsoluble extracts were isolated and purified by silica gel and RP-C18 column chromatography. Their structures were identified by spectral analysis. Anti-proliferative effects of saponins against HepG2 cells were evaluated by MTT assay in vitro. RESULTS Five compounds were isolated and identified as diosgenin ( Ⅰ), trillin ( Ⅱ), diosgenin diglucoside ( Ⅲ), deltonin ( Ⅳ), zingiberensis saponin I ( Ⅴ), respectively. These five compounds showed remarkable anti-proliferative effects against HepG2 cells and the compound Ⅴ showed the highest potency against HepG2 cells. CONCLUSION Zingiberensis saponin I ( Ⅴ) has significant anti-cancer activity which may be developed as promising anti-cancer drug

Density

1.5±0.1 g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

Boiling Point

Melting Point

285-287 °C (methanol)

InChl

InChI=1S/C51H82O22/c1-20-8-13-51(64-19-20)21(2)32-28(73-51)15-27-25-7-6-23-14-24(9-11-49(23,4)26(25)10-12-50(27,32)5)66-48-44(72-45-38(60)36(58)33(55)22(3)65-45)40(62)42(31(18-54)69-48)70-47-41(63)43(35(57)30(17-53)68-47)71-46-39(61)37(59)34(56)29(16-52)67-46/h6,20-22,24-48,52-63H,7-19H2,1-5H3/t20-,21+,22+,24+,25-,26+,27+,28+,29-,30-,31-,32+,33+,34-,35-,36-,37+,38-,39-,40+,41-,42-,43+,44-,45+,46+,47+,48-,49+,50+,51-/m1/s1

InChl Key

XJOTXMLDNWCDRH-HAUZKCKMSA-N

WGK Germany

RID/ADR

HS Code Reference

2933990000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:91653-50-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

6235520

Abstract

Deltonin or diosgenin-3-0-alpha-L-rhamnopyranosyl-(1—-2)-[beta-D- glucopyranosyl-(1—-4)-]-beta-D-glucopyranoside, m. p. 282 degrees, [alpha] 20(546): -96.4 degrees (c 1, pyridine) and a new oligospirostanoside beta-D-glucopyranosyl-(1—-3” Glcp)-deltonin, m. p. 242-243 degrees, [alpha]20(546): -63.7 degrees (c 1, pyridine) were isolated from rhizomes of Dioscorea caucasica.

Title

[Steroid saponins from the rhizomes of Dioscorea caucasica Lipsky]

Author

I S Vasil'eva, V A Paseshnichenko, A R Guseva

Publish date

May-Jun 1984